AUTOIMMUNE MECHANISMS IN DIABETIC NEUROPATHY

糖尿病神经病的自身免疫机制

• 批准号: 7603776
• 负责人: JOHN W WILEY
• 金额: $ 1.65万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603776
• 关键词: Affect; American; Antibodies; Autoantibodies; Autoimmune Process; Blood; Cells; Complication; Computer Retrieval of Information on Scientific Projects Database; Development; Diabetes Mellitus; Diabetic Neuropathies; Diagnosis; Enrollment; Evaluation; Eye; Feeling; Funding; Future; Grant; Immune system; Infection; Injury; Institution; Kidney; Lead; Leg; Natural History; Nervous System Physiology; Nervous system structure; Neurons; Newly Diagnosed; Non-Insulin-Dependent Diabetes Mellitus; Numbers; Numbness; Pain; Participant; Patients; Play; Proteins; Reporting; Research; Research Personnel; Resources; Role; Source; Testing; Time; Tissues; United States National Institutes of Health; design; diabetic; foot; healthy volunteer; injured; nerve injury

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Does the body's immune system play a role in the development of problems involving the nervous system in people with diabetes? Diabetes is known to be connected with problems involving the eyes, kidneys and nervous system. Little is known about why people develop problems with their nervous system in diabetes. Patients with diabetes report: -Pain -Tingling -Numbness and loss of feeling in their feet and legs. An increased number of antibodies in the blood that can attach to nerve cells and injure the nerve cells have been reported in patients with diabetes. Antibodies are proteins made by your body. The antibodies protect you from infections. Sometimes our body will make antibodies that attach to our own tissues. This type of antibody injures the tissues. These antibodies are called autoantibodies. It is not known why or when these autoantibodies develop in diabetes. We don't know whether these antibodies contribute to the development of complications involving the nervous system. Our study is designed to help answer the following questions: 1. When do antibodies begin to appear in people with diabetes? 2. Does the presence of antibodies increase over time? 3. Do the antibodies attach to nerve cells? 4. If these antibodies attach to nerve cells, what are they specifically attaching to? 5. Do these antibodies injure nerve cells? 6. If the antibodies cause injury to nerve cells, how does this happen? We hope that answering these questions will lead to better treatments for the nervous system problems associated with diabetes in the future. Type 2 Diabetes is the most common form of diabetes and it affects millions of Americans every year. We will examine the hypothesis that a significant percentage of patients with Type 2 Diabetes will slowly develop autoantibodies during the course of their illness and that these autoantibodies contribute to the injury and loss of cells in the nervous system, a well-known complication in long-term diabetic patients. A total of 120 people 18 years or older will be enrolled into this study. Two groups of people with Type 2 Diabetes and one group of healthy volunteers will be studied. Group 1 will include people with Type 2 Diabetes newly diagnosed and up to 2 years prior to their start in this study. Group 2 will include people with Type 2 Diabetes diagnosed 7 to 9 years prior to their start in this study, and Group 3 will include healthy volunteers. All groups will undergo a thorough examination of their nervous system function and have blood drawn to screen for the presence of autoantibodies. All participants will undergo re-evaluation between four to five years after the initial testing. These studies will help to determine the significance of autoimmune mechanisms in the natural history of nerve injury that occurs in Type 2 Diabetes Mellitus.'

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 人体的免疫系统是否在涉及糖尿病患者神经系统的问题的发展中起作用？ 众所周知，糖尿病与涉及眼睛，肾脏和神经系统的问题有关。 关于人们为何在糖尿病中出现神经系统问题的原因知之甚少。 糖尿病患者报告： -疼痛 - 刺 - 脚和腿部的肢体和失去感觉。 糖尿病患者的血液中可能附着在神经细胞上并损害神经细胞的抗体数量增加。抗体是您身体生产的蛋白质。 抗体可保护您免受感染。 有时，我们的身体会产生附着在我们自己的组织上的抗体。 这种类型的抗体会损害组织。 这些抗体称为自身抗体。 尚不知道这些自身抗体在糖尿病中发生的原因或何时出现。 我们不知道这些抗体是否有助于涉及神经系统的并发症的发展。 我们的研究旨在帮助回答以下问题： 1。糖尿病患者何时开始出现抗体？ 2。抗体的存在会随着时间而增加吗？ 3。抗体是否附着在神经细胞上？ 4。如果这些抗体附着在神经细胞上，它们专门附着在什么？ 5。这些抗体会损害神经细胞吗？ 6。如果抗体会对神经细胞造成损伤，这是如何发生的？ 我们希望回答这些问题将为将来与糖尿病有关的神经系统问题提供更好的治疗。 2型糖尿病是最常见的糖尿病形式，每年会影响数百万美国人。 我们将研究以下假设：2型糖尿病患者在疾病过程中会慢慢发展自身抗体，并且这些自身抗体会导致神经系统中细胞的损伤和细胞损失，这是长期糖尿病患者的众所周知并发症。 这项研究将招收18岁或以上的120人。 将研究两组2型糖尿病患者和一组健康的志愿者。 第1组将包括新诊断的2型糖尿病患者，并在本研究开始之前长达2年。 第2组将包括在本研究开始前7至9年诊断为2型糖尿病的患者，第3组将包括健康的志愿者。 所有小组都会对其神经系统功能进行彻底检查，并吸收血液以筛选自身抗体的存在。所有参与者将在初次测试后的四到五年之间进行重新评估。这些研究将有助于确定自身免疫机制在2型糖尿病中发生的神经损伤自然史上的重要性。