INFLAMMATORY PROFILES OF CHILDREN AT HIGH RISK FOR ATHEROSCLEROSIS

动脉粥样硬化高危儿童的炎症特征

• 批准号: 7380751
• 负责人: Sarah D DE FERRANTI
• 金额: $ 13.22万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380751
• 关键词: INFLAMMATORY; PROFILES; CHILDREN; RISK; ATHEROSCLEROSIS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Overall goal is to better understand the relationship between elevated levels of inflammatory markers in childhood and proven cardiovascular risk factors, by describing inflammatory makers and known cardiovascular risk factors in children with parents or grandparents who have premature atherosclerotic disease (cases) as defined by the National Cholesterol Education Program (NCEP)(1) and the American Academy of Pediatrics (AAP), (2) and controls without such a family history. Cases and controls will be further divided into groups with and without hyperlipidemia to allow clarification of interaction between hyperlipidemia and family history of early atherosclerosis.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。总体目标是通过描述炎症制造商和已知的患有早产的动脉粥样硬化疾病（病例）的儿童的炎症制造商和已知的心血管危险因素来更好地了解儿童期炎症标志物水平升高与经过证明的心血管危险因素之间的关系。病例和对照将进一步分为有或没有高脂血症的组，以阐明高脂血症与早期动脉粥样硬化的家族史之间的相互作用。