Low CV Risk, Ages 25-44 & CV/non-CV Outcomes, Ages 65+

心血管风险低，年龄 25-44 岁

• 批准号: 7356447
• 负责人: Martha L Daviglus
• 金额: $ 73.25万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7356447
• 关键词: Accounting; Address; Age; Cardiovascular Diseases; Cardiovascular system; Characteristics; Chicago; Cholesterol; Clinical; Coronary heart disease; Data; Databases; Depth; Diabetes Mellitus; Disease; Disease Marker; Elderly; Epidemic; Epidemiologic Studies; Ethnic Origin; Freedom; Future; Gender; Goals; Health; Healthy People 2010; Heart; Impairment; Individual; Inflammation; Inflammatory; Knowledge; Life; Longevity; Measurable; Measures; Medical Care Costs; Medicare; Methods; Minority; Outcome; Participant; Pathway interactions; Performance; Persons; Physical Function; Policies; Population; Probability; Public Policy; Quality of life; Questionnaires; Recommendation; Recording of previous events; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Sampling; Score; Serum; Smoking; Socioeconomic Status; Stroke; Sum; Testing; Time; Weight; Woman; base; cardiovascular disorder risk; cohort; cost; design; expectation; experience; follow-up; fundamental research; health disparity; health related quality of life; healthy aging; men; middle age; mortality; programs; response

DESCRIPTION (provided by applicant): Background: It has been demonstrated that with low risk (LR), i.e., favorable levels of all readily measurable major risk factors, as defined in national policy recommendations and objectives for 2010 (SBP/DBP <120/<80 mmHg, serum total cholesterol <200 mg/dl, BMI<25 kg/m2, no smoking, no diabetes, no MI history), clinical CHD/CVD is rare (endemic, not epidemic), estimated longevity is increased by several years, and medical care costs in older persons are sizably reduced. Significant knowledge gaps remain to be closed, especially on the relevance of low risk in young adulthood and early middle age for achieving CVD-free healthy aging, i.e., not only less clinical but also less non- invasively detectable subclinical CVD, more favorable levels of inflammatory markers possibly related to CVD, and higher levels of physical performance and physical functioning. Data do not exist on these matters. Aims: General: To expand ~ in an efficient and cost-effective way - the database of the Chicago Heart Association (CHA) Study with new data to make a further major contribution in knowledge about the decades-long consequences of low risk (LR) present in young adulthood/early middle-age, particularly its relevance for achieving freedom in older age from non-invasively detectable subclinical CHD/CVD, inflammatory markers of CHD/CVD risk, and impairment of physical performance and functioning -- in both genders and across SES strata of varied ethnicity including people already long- lived (ages 75+). To achieve Aims (General and Specific), weighted random samples of the CHA cohort baseline ages 25-44 in 1967-73 - low risk (n=600) and not low risk (n=900) - are to be examined in 2006-2009 at ages 65-79. Specific Aims: Assess long-term relationship of baseline LR status (ages 25-44) with: 1) presence and extent of subclinical atherosclerotic disease at ages 65-79; 2) levels of CVD- related markers of inflammation at ages 65-79; 3) levels of objectively measured physical performance/function at ages 65-79. 4) Determine role of current subclinical atherosclerotic disease and inflammatory markers in accounting for associations of LR profile at younger age with physical performance/function at older age. Significance: The expected new data from the proposed research can serve to clarify and inform strategic priorities for attaining the two stipulated Healthy People 2010 primary goals, "increase quality and years of healthy life" and "eliminate health disparities."

描述（由申请人提供）： 背景：已经证明，低风险（LR），即所有可容易测量的主要风险因素均处于有利水平，如 2010 年国家政策建议和目标中所定义（SBP/DBP <120/ <80 mmHg、血清总胆固醇<200 mg/dl、BMI<25 kg/m2、不吸烟、无糖尿病、无心肌梗死病史），临床 CHD/CVD 罕见（地方性、而非流行病），预计寿命将延长数年，老年人的医疗费用也将大幅降低。仍存在重大知识差距，特别是在青年期和中年早期的低风险与实现无 CVD 健康老龄化的相关性方面，即，不仅临床较少，而且非侵入性可检测的亚临床 CVD 也较少，更有利的水平可能与心血管疾病相关的炎症标志物，以及更高水平的身体表现和身体功能。这些问题上不存在数据。目标： 总则：以高效且具有成本效益的方式扩展芝加哥心脏协会 (CHA) 研究的数据库，使用新数据，为了解低风险 (LR) 长达数十年的后果的知识做出进一步的重大贡献存在于青年期/中年早期，特别是其与老年时摆脱非侵入性可检测的亚临床 CHD/CVD、CHD/CVD 风险的炎症标志物以及身体机能和功能损伤的相关性 - 无论男女跨社会经济地位不同种族的阶层，包括已经长寿的人（75 岁以上）。为了实现目标（一般目标和具体目标），1967-73 年 CHA 队列基线年龄 25-44 岁的加权随机样本 - 低风险 (n=600) 和非低风险 (n=900) - 将在 2006 年进行检查 - 2009年65-79岁。具体目标：评估基线 LR 状态（25-44 岁）与以下因素的长期关系：1) 65-79 岁亚临床动脉粥样硬化疾病的存在和程度； 2) 65-79岁CVD相关炎症标志物水平； 3) 65-79 岁客观测量的身体表现/功能水平。 4) 确定当前亚临床动脉粥样硬化疾病和炎症标志物在解释年轻时 LR 谱与老年时身体表现/功能之间的关联中的作用。意义：拟议研究中预期的新数据可用于澄清和告知战略优先事项，以实现《2010 年健康人民》规定的两个主要目标：“提高健康生活质量和年数”和“消除健康差距”。