PATTERN COMPLETION AND PREDICTION ERROR IN HIPPOCAMPUS: A HI-RES FMRI STUDY

海马体模式补全和预测误差：高分辨率 FMRI 研究

• 批准号: 7358804
• 负责人: JANICE CHEN
• 金额: $ 0.31万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358804
• 关键词: PATTERN; COMPLETION; PREDICTION; ERROR; HIPPOCAMPUS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hippocampus is known to be critical for declarative memory, though the functional contributions of the subfields of human hippocampus remain underspecified. The anatomical organization of hippocampus¿¿which includes dentate gyrus, CA3, CA1, and subiculum¿¿suggests that CA3 and CA1 may differentially subserve memory-based prediction and the detection of prediction error (Lisman & Grace, 2005). In particular, CA3 is hypothesized to support the encoding of conjunctive memories that are subsequently ¿pattern completed¿ at retrieval, in essence making predictions about the present based on knowledge acquired in the past. CA3 is thought to pass these predictions to CA1, which is positioned to compare this output from memory with input from entorhinal cortex that transmits the present state of ¿sensory reality¿. To examine the functional contributions of CA3 and CA1 to pattern completion and the detection of prediction error, we used high-resolution fMRI to measure the functional response of MTL cortices¿¿perirhinal, parahippocampal, and entorhinal¿¿and the subfields of hippocampus proper. During intentional encoding (not scanned), subjects viewed face-house pairs. Subsequently, subjects were scanned at 3T (effective TR=2s, TE=41ms, 1.7 x 1.7 x 3 mm) while performing cued-recall followed by a yes/no probe decision. On each test trial, one element of a studied pair served as a retrieval cue, which was followed by a 7.5-s delay during which the subject attempted to retrieve the associate. Following the delay, a probe was presented¿¿either the correct associate (match) or an incorrect item (mismatch); subjects had 750 ms to make a yes/no response (this speeded response encouraged pattern completion during the delay period).

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是针对该中心的，这不是调查人员的机构。尽管人类海马子场的功能贡献仍然不足，但海马对声明性记忆至关重要。海马的解剖组织包括齿状回，CA3，CA1和亚曲，这表明CA3和CA1可能对基于内存的预测以及对预测误差的检测可能有所不同（Lisman＆Grace，2005年）。特别是，假设CA3以支持随后在检索时完成模式的结合记忆的编码，本质上是基于过去获得的知识对当前的预测进行了预测。 CA3被认为将这些预测传递给CA1，它的定位是将记忆中的输出与intorhinal Cortex的输入进行比较，该输入传递了当前的感觉现实状态。为了检查CA3和CA1对模式完成的功能贡献和检测预测误差，我们使用高分辨率fMRI来测量MTL Cortices»»Perirhinal，parahippocampal和intorhialnal和Intorhinal�和Hippocampus的子场的功能响应。在有意编码（未扫描）期间，受试者会查看面积对。随后，在3T（有效的TR = 2s，TE = 41ms，1.7 x 1.7 x 3 mm）下扫描受试者，同时执行提示回合，然后进行是/否探测决策。在每个测试试验中，一对二对的一个元素用作检索提示，随后是7.5 s延迟，在此期间，受试者试图检索合伙人。延迟后，提出了探针````正确的''（匹配）或不正确的项目（不匹配）；受试者有750毫秒来做出是/否响应（这种加快响应鼓励在延迟期间完成模式完成）。