PATTERN COMPLETION AND PREDICTION ERROR IN HIPPOCAMPUS: A HI-RES FMRI STUDY

海马体模式补全和预测误差：高分辨率 FMRI 研究

• 批准号: 7358804
• 负责人: JANICE CHEN
• 金额: $ 0.31万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358804
• 关键词: PATTERN; COMPLETION; PREDICTION; ERROR; HIPPOCAMPUS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hippocampus is known to be critical for declarative memory, though the functional contributions of the subfields of human hippocampus remain underspecified. The anatomical organization of hippocampus¿¿which includes dentate gyrus, CA3, CA1, and subiculum¿¿suggests that CA3 and CA1 may differentially subserve memory-based prediction and the detection of prediction error (Lisman & Grace, 2005). In particular, CA3 is hypothesized to support the encoding of conjunctive memories that are subsequently ¿pattern completed¿ at retrieval, in essence making predictions about the present based on knowledge acquired in the past. CA3 is thought to pass these predictions to CA1, which is positioned to compare this output from memory with input from entorhinal cortex that transmits the present state of ¿sensory reality¿. To examine the functional contributions of CA3 and CA1 to pattern completion and the detection of prediction error, we used high-resolution fMRI to measure the functional response of MTL cortices¿¿perirhinal, parahippocampal, and entorhinal¿¿and the subfields of hippocampus proper. During intentional encoding (not scanned), subjects viewed face-house pairs. Subsequently, subjects were scanned at 3T (effective TR=2s, TE=41ms, 1.7 x 1.7 x 3 mm) while performing cued-recall followed by a yes/no probe decision. On each test trial, one element of a studied pair served as a retrieval cue, which was followed by a 7.5-s delay during which the subject attempted to retrieve the associate. Following the delay, a probe was presented¿¿either the correct associate (match) or an incorrect item (mismatch); subjects had 750 ms to make a yes/no response (this speeded response encouraged pattern completion during the delay period).

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一，该子项目和研究者 (PI) 可能已从其他 NIH 来源获得主要资助，因此可以在其他 CRISP 机构中得到体现。所列出的是该中心，该中心不一定是研究人员的机构。众所周知，海马体对于陈述性记忆至关重要，尽管人类海马体子区域的功能贡献仍未明确。海马体?? ¿其中包括齿状回、CA3、CA1 和下托。 ¿表明 CA3 和 CA1 可能有差异地促进基于记忆的预测和预测错误的检测（Lisman & Grace，2005）。特别是，CA3 被清除以支持随后的连接记忆的编码。图案完成??在检索时，本质上基于过去获得的知识对当前进行预测被认为是将这些预测传递给 CA1，CA1 的位置是将内存的输出与传输当前状态的内嗅皮层的输入进行比较。感官现实¿为了检查 CA3 和 CA1 对模式完成和预测误差检测的功能贡献，我们使用高分辨率功能磁共振成像来测量 MTL 皮质的功能反应。 ¿鼻周、海马旁和内嗅 ¿ ¿在有意编码（未扫描）期间，受试者观察面部对，随后，在执行提示时以 3T（有效 TR=2s，TE=41ms，1.7 x 1.7 x 3 mm）扫描受试者。回忆之后是/否的探测决定 在每次测试中，所研究的一对元素中的一个元素作为检索线索，随后是 7.5 秒的延迟。在延迟之后，对象试图找回同事，并提出了一个探测器。 ¿正确的关联（匹配）或不正确的项目（不匹配）受试者有 750 毫秒的时间做出是/否反应（这种快速反应鼓励延迟期间完成模式）。