ASSOCIATIVE RETRIEVAL AND MISMATCH SIGNALS IN THE CA FIELDS OF HUMAN HIPPOCAMPUS

人类海马 CA 区的联想检索和失配信号

• 批准号: 7722922
• 负责人: JANICE CHEN
• 金额: $ 0.28万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722922
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Cues; Detection; Elements; Functional Magnetic Resonance Imaging; Funding; Grant; Hippocampus (Brain); Housing; Human; Institution; Knowledge; Measures; Memory; Methods; Output; Pattern; Personal Satisfaction; Positioning Attribute; Research; Research Personnel; Resolution; Resources; Retrieval; Role; Scanning; Sensory; Signal Transduction; Source; Thinking; United States National Institutes of Health; base; dentate gyrus; entorhinal cortex; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While the role of the hippocampus in declarative memory is well established, the mechanisms subserved by component subfields remain underspecified. Within the hippocampuswhich includes dentate gyrus, CA3, CA1, and subiculumit has been hypothesized that CA3 and CA1 differentially support memory-based associative predictions and the detection of associative prediction error. From this perspective, CA3 is posited to encode conjunctive memories that are subsequently "pattern completed" during associative retrieval, in essence making predictions about the present based on associative knowledge acquired in the past. CA3 is thought to pass these predictions to CA1, which is positioned to compare this output from memory with input from entorhinal cortex that transmits the present state of "sensory reality". Specific Aims: We seek to examine the functional contributions of human CA3 and CA1 to associative retrieval and the detection of associative prediction error. Methods and Materials: We used high-resolution fMRI to measure the functional response of MTL corticesperirhinal, parahippocampal, and entorhinaland the subfields of hippocampus. Subjects encoded face-house pairs, and were subsequently scanned at 3T while performing cued-recall followed by a match/mismatch probe decision. On each recall trial, one element of a studied pair served as the retrieval cue, which was followed by a 7.5-s delay during which the subject attempted to retrieve the associate. Following the delay, a probe was presented¿either the correct associate (match) or an incorrect item (mismatch); subjects had 750 ms to respond.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 对于中心来说，它不一定是研究者的机构。 虽然海马在陈述性记忆中的作用已被充分确定，但在海马（包括齿状回、CA3、CA1 和下托）中，各组成子域所促进的机制仍不清楚，CA3 和 CA1 差异支持基于记忆的联想。从这个角度来看，CA3 的定位是对随后“模式完成”的连接记忆进行编码。联想检索，本质上是根据过去获得的联想知识对当前进行预测，被认为将这些预测传递给 CA1，CA1 的位置是将内存的输出与传输“当前状态”的内嗅皮层的输入进行比较。感官现实”。 具体目标：我们试图检查人类 CA3 和 CA1 对联想检索和联想预测错误检测的功能贡献。 方法和材料：我们使用高分辨率功能磁共振成像来测量 MTL 皮质的嗅周、海马旁和内嗅以及海马子区域的功能反应，并随后在 3T 下进行扫描，同时进行提示回忆。在每次回忆试验中，匹配/不匹配探测决策中，所研究的一对元素中的一个元素作为检索线索，随后是一个检索线索。 7.5 秒的延迟，在此期间受试者试图找回同事，随后出现了一个探针 ¿正确的联想（匹配）或错误的项目（不匹配）；受试者有 750 毫秒的时间做出反应。