CIMA (CASPASE-INDEPENDENT MITOTIC APOPTOSIS)

CIMA（不依赖CASPASE的有丝分裂凋亡）

• 批准号: 7358133
• 负责人: KATSUMI KITAGAWA
• 金额: $ 0.2万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358133
• 关键词: CIMA; CASPASE; INDEPENDENT; MITOTIC; APOPTOSIS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. CIMA (caspase-independent mitotic apoptosis) is a novel mitotic cell death that we have recently found. This cell death occurs when Bub1 (a spindle checkpoint protein kinase)- deficient cells have defects in the kinetochore-microtubule attachment. To define the morphological futures (particularly mitochondria) of this novel type of cell death, Kitigawa plans to perform transmission electron microscopy and electron tomography.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。 CIMA（caspase非依赖性有丝分裂凋亡）是我们最近发现的一种新型有丝分裂细胞死亡。当Bub1（纺锤体检查点蛋白激酶） - 缺陷细胞具有缺陷的动物学微管附着时，会发生这种细胞死亡。为了定义这种新型细胞死亡类型的形态期货（尤其是线粒体），Kitigawa计划执行传输电子显微镜和电子断层扫描。