CIMA (CASPASE-INDEPENDENT MITOTIC APOPTOSIS)

CIMA（不依赖CASPASE的有丝分裂凋亡）

• 批准号: 7601061
• 负责人: KATSUMI KITAGAWA
• 金额: $ 0.22万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601061
• 关键词: Aneuploidy; Apoptosis; BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog; BUB1 gene; Caspase; Cell Death; Cells; Chromosomal Instability; Computer Retrieval of Information on Scientific Projects Database; Cultured Cells; Electron Microscopy; Funding; Grant; Institution; Mediating; Mitochondria; Mitotic; Research; Research Personnel; Resources; Source; Structure; System; United States National Institutes of Health; electron tomography; neoplastic cell; prevent; response; tumor; tumorigenesis

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In order to aid the study of mitochondrial structure, Dr. Perkins, who conducts electron microscopy and electron tomography on mitochondria, agreed to look at our treated cells. Little is known about the relationship between the spindle checkpoint and cell death or apoptosis. Many tumor cells have a diminished, but not absent, spindle checkpoint response. caspase-independent mitotic cell death (CIMCD) occurs when BUB1 function is partly but not completely disrupted as in chromosome instability (CIN) tumors. CIMCD may be an alternative system to prevent aneuploidy and, therefore, probably tumorigenesis when the BUB1-mediated activation of the spindle checkpoint fails. Dr. Perkins is providing a structural analysis of CIMCD in cultured cells, not only of mitochondria, but also of general cytoplasmic features.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 为了帮助研究线粒体结构，在线粒体上进行电子显微镜和电子层析成像的珀金斯博士同意看我们的经过处理的细胞。 关于主轴检查点与细胞死亡或凋亡之间的关系知之甚少。许多肿瘤细胞的主轴检查点响应减少但不存在。当Bub1功能部分而不是完全破坏染色体不稳定性（CIN）肿瘤时，就会发生非胱天冬酶无关的有丝分裂细胞死亡（CIMCD）。 CIMCD可能是预防非整倍性的替代系统，因此，当BUB1介导的主轴检查点的激活失败时，可能是肿瘤发生的。 珀金斯博士不仅对线粒体，而且还提供了一般细胞质特征的培养细胞中CIMCD的结构分析。