A NOVEL APPROACH TO GERM-LINE PRESERVATION IN MACAQUES

猕猴种系保存的新方法

• 批准号: 7349697
• 负责人: STUART A MEYERS
• 金额: $ 4.97万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349697
• 关键词: NOVEL; APPROACH; GERM; LINE; PRESERVATION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Spermatogonial stem cell transplantation may provide a method by which unique genotypes may be proliferated as well as a novel method to generate transgenic animals. Immediate objectives are to develop a successful method to isolate and enrich nonhuman primate germ line precursor cells and transplant spermatogonial stem cells from genetically unique male macaques to immunodeficient mice and recipient male macaques.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。目的：精子干细胞移植可以提供一种可以通过这种方法来增殖独特的基因型，以及一种新的生成转基因动物的方法。直接的目标是开发一种成功的方法，以分离和富集非人类灵长类动物的生殖线前体细胞和移植精子干细胞从遗传独特的雄性猕猴到免疫缺陷的小鼠和受体男性猕猴。