A Durable Muscle-Prosthetic Bond For Artificial Tendons

用于人工肌腱的耐用肌肉假体粘合

基本信息

批准号：
6993321
负责人：
DAVID B MELVIN
金额：
$ 14.93万
依托单位：
CARDIOENERGETICS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-15 至 2006-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6993321
关键词：
biomaterial development /preparation biomaterial interface interaction biomechanics bone prosthesis goats histology light microscopy polymers shear stress tendons tensile strength

项目摘要

DESCRIPTION (provided by applicant): Present means of tendon reconstruction, ranging from allografted and autografted tendons to neotendons generated by resorbable 'scaffolding', do not well serve at least two groups of people. First, after prosthetic replacement of extirpated cancerous bones there is no consistently reliable means of muscle reattachment to otherwise quite adequate bone replacement prostheses. Second, though traditional tendon transfer may dramatically aid some children with cerebral palsy or peripartum nerve injury, many more are limited by the length and position of native tendons. Both these people and others would benefit from a truly artificial tendon-if one existed. Bone-replacement reconstruction would then be straightforward joining of inert materials; tendon transfer would no longer be limited by length and location: a prosthesis could be made any length. There is reason to believe a new durable muscle-to-prosthesis coupling technology, developed for delivering muscle-power to circulatory support devices with very successful animal results (separation strengths far exceeding demand), could yield a coupling serving these orthopedic needs fully as well as-or better than- its original intent. This device works by dispersing ultrafine polymer fibers in the distal muscle substance to dramatically increase force-transfer surface, with proportionally dramatic interface-stress reduction. We will simulate the dilemma of reattaching native tendons to bone-replacement prostheses by developing a device suitable for joining muscles not to their previous insertions sites but rather to metal bone plates in the region. A large muscle in each of eight adult goats will be in this way fixed to the surface of asteel bone plate for 60 days. We have developed and refined this model in a plot trial. Mechanical bond strength relative to standard surgical controls, and histologic tissue-prosthetic interface will be examined. The experimental data will be analyzed for significance. Material fatigue life of devices will be examined through cyclic accelerated loading. Successful demonstration of feasibility would justify Phase II level development-extensive, realistically long-term reconstruction with full bone prostheses in strategic partnership with a developer of these prostheses, as well as serious study of tendon transfer application.

描述（由申请人提供）：现有的肌腱重建方法，从同种异体移植和自体移植肌腱到通过可吸收“支架”产生的新肌腱，不能很好地服务于至少两组人。首先，在对摘除的癌骨进行假体置换后，没有一致可靠的方法将肌肉重新附着到其他相当足够的骨置换假体上。其次，虽然传统的肌腱移植可能会极大地帮助一些患有脑瘫或围产期神经损伤的儿童，但更多的儿童受到天然肌腱的长度和位置的限制。这些人和其他人都将受益于真正的人工肌腱——如果存在的话。骨替代重建将是惰性材料的直接连接；肌腱转移将不再受到长度和位置的限制：假肢可以制成任何长度。我们有理由相信，一种新型耐用的肌肉与假体耦合技术，旨在将肌肉力量输送到循环支持装置，并在动物身上取得了非常成功的结果（分离强度远远超过需求），也可以产生完全满足这些骨科需求的耦合技术符合或优于其初衷。该装置的工作原理是将超细聚合物纤维分散在远端肌肉物质中，以显着增加力传递表面，并相应地显着减少界面应力。我们将通过开发一种适合将肌肉连接到该区域的金属骨板而不是其先前插入部位的装置来模拟将天然肌腱重新连接到骨替代假体上的困境。将八只成年山羊的一块大肌肉以这种方式固定在钢骨板的表面上60天。我们在情节试验中开发并完善了这个模型。将检查相对于标准手术控制的机械粘合强度以及组织学组织-假体界面。将分析实验数据的显着性。通过循环加速加载来检验装置的材料疲劳寿命。成功的可行性论证将证明第二阶段开发的合理性——与这些假体开发商建立战略合作伙伴关系，利用全骨假体进行广泛的、现实的长期重建，以及对肌腱转移应用的认真研究。