The sound of fear: high resolution and whole brain fMRI

恐惧的声音：高分辨率和全脑功能磁共振成像

• 批准号: 7126383
• 负责人: ANNEMIEKE M SCHOUTE
• 金额: $ 3.03万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-20 至 2007-12-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7126383
• 关键词: amygdala; auditory cortex; auditory pathways; auditory stimulus; behavioral /social science research tag; behavioral extinction; bioimaging /biomedical imaging; brain electrical activity; brain imaging /visualization /scanning; brain mapping; clinical research; conditioning; evoked potentials; fear; frontal lobe /cortex; functional magnetic resonance imaging; human subject; learning; neuropsychology; predoctoral investigator; sound perception; thalamus

DESCRIPTION (provided by applicant): Providing a direct link between animal and human models of fear learning and extinction is vital to developing knowledge that can be translated to the treatment for human anxiety disorders. Although claims from previous studies in humans are largely consistent with animal models, these claims are limited for two reasons: 1. The paradigms used differed across species (i.e., visual vs. auditory conditioning). 2. Standard brain imaging techniques are limited in examining neural circuitry in humans. The proposed research will provide a more direct link by using auditory fear conditioning, a paradigm extensively studied in animals and by using technical advances in functional magnetic resonance imaging (fMRI). Crucial regions of the auditory fear circuit, the amygdala, auditory thalamus, auditory cortex and medial prefrontal cortex, as well as their subregions will be studied using event-related fMRI. Better understanding of cross-species analogies will be achieved by: 1. Using whole brain event-related fMRI investigating the neural circuitry underlying auditory fear conditioning and extinction in humans. 2. Using high-resolution fMRI to achieve insight into the involvement of subregions of the auditory fear circuit during fear learning and extinction in humans

描述（由申请人提供）：提供动物和人类恐惧学习和消退模型之间的直接联系对于开发可转化为人类焦虑症治疗的知识至关重要。尽管之前的人类研究主张与动物模型基本一致，但这些主张受到以下两个原因的限制： 1. 不同物种使用的范式不同（即视觉条件反射与听觉条件反射）。 2. 标准脑成像技术在检查人类神经回路方面受到限制。拟议的研究将通过使用听觉恐惧调节（一种在动物中广泛研究的范式）以及功能性磁共振成像（fMRI）的技术进步来提供更直接的联系。听觉恐惧回路的关键区域、杏仁核、听觉丘脑、听觉皮层和内侧前额叶皮层及其子区域将使用事件相关功能磁共振成像进行研究。通过以下方式可以更好地理解跨物种类比： 1. 使用全脑事件相关功能磁共振成像研究人类听觉恐惧调节和消退的神经回路。 2. 使用高分辨率功能磁共振成像来深入了解人类恐惧学习和消退过程中听觉恐惧回路子区域的参与情况