EFFECTS OF SMOKING AND CESSATION ON BRAIN ACTIVITY

吸烟和戒烟对大脑活动的影响

• 批准号: 7375112
• 负责人: ALAN S BLOOM
• 金额: $ 2.38万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375112
• 关键词: EFFECTS; SMOKING; CESSATION; BRAIN; ACTIVITY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to assess alterations in cerebral activation patterns resulting from cigarette smoking and withdrawal from chronic nicotine self-administration. Functional MRI will be used to measure the ability of cognitive and motor tasks to increase cerebral activity dependent upon smoking status, withdrawal time, and intensity of withdrawal symptoms. 110 chronic cigarette smokers and 40 age- and education-matched controls (18-50 years) will be screened by telephone, then visit the GCRC for informed consent, history, and physical exam, and structured interview and questionnaires to permit scoring for nicotine dependence. Exhaled CO will be measured. Subjects will then undergo whole body structural and functional MRI scanning (3T), during which task activation and performance testing will be performed. Subjects in SA 1 (differences between chronic smokers and nonsmokers in task activation) will be scanned once, 5 times in SA 2 (altered task activation with cessation), and 4 times in SA 3. Subjects in SA 3 (role of nicotine in the withdrawal syndrome) will receive IV and/or patch nicotine replacement. GCRC nursing support is requested to obtain and process blood and urine samples, assist with consenting, and place IV lines. GCRC nurses are also needed to assist with drug run-up procedures on the IV nicotine subjects. GCRC Biostatistics is needed for data analysis, the fMRI Core for scanning analysis. GCRC support is also requested for scanning fees, CBC and AST testing, and urine drug triage, pregnancy testing, and cotidine testing.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项研究的目的是评估因吸烟和从慢性尼古丁自我给药中退出而导致的脑激活模式的改变。功能性MRI将用于衡量认知和运动任务增加脑活动的能力，取决于吸烟状况，戒断时间和戒断症状的强度。 110名慢性吸烟者和40岁和教育匹配的控制（18-50岁）将通过电话进行筛查，然后访问GCRC以获取知情同意，历史和身体检查，以及结构化的访谈和问卷，以允许对尼古丁依赖进行评分。将测量呼出的CO。然后，受试者将接受全身结构和功能性MRI扫描（3T），在此期间将进行任务激活和性能测试。 SA 1中的受试者（慢性吸烟者和任务激活中的非吸烟者之间的差异）将在SA 2中进行5次扫描（戒烟的任务激活改变），而在SA 3中进行了4次。SA3中的受试者（在戒断综合症中的作用）将接受IV和/或Patch Nicotine替代品。要求GCRC护理支持获取和处理血液和尿液样本，协助同意并放置IV线。还需要GCRC护士来协助静脉注射尼古丁受试者进行药物升级程序。数据分析需要GCRC生物统计学，这是扫描分析的fMRI核心。还要求GCRC支持扫描费，CBC和AST测试以及尿液药物分类，妊娠试验和西他丁测试。