ASSESSING HIGH DIETARY VITAMIN A

评估高膳食维生素 A

• 批准号: 7349412
• 负责人: SHERRY A TANUMIHARDJO
• 金额: $ 2.72万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349412
• 关键词: ASSESSING; DIETARY; VITAMIN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To further define the effects of chronically high dietary vitamin A. Recent work examining the vitamin A (VA) status of rhesus monkeys (Macaca mulatta) used as models for human biomedical research revealed subtoxic hepatic VA concentrations. Marmoset monkeys (Callithrix jacchus), also showed high VA levels and high serum retinyl ester concentration. Both species consumed common research diets that provided up to four times the amount of VA recommended by the National Research Council. Further interpretation of these findings is limited to tissue retinol and retinyl ester profiles and extrapolation from other species rather than direct comparison to normal values. To further define VA status in rhesus monkeys, male rhesus monkeys were used for a study that involved stable isotopes and liver biopsies. While the VA analysis is still in process, we found ¿abnormal¿ values in the chemistry screening profiles in 10 of the 16 male rhesus monkeys (age range 8 to 15 years). Among the monkeys, these included elevated alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase, and aspartate aminotransferase. Elevations of these enzymes are cause for concern as they are all markers of liver disease or malfunction, which is a direct outcome of vitamin A toxicity. This research used WNPRC Research Services.

该主题项目是利用NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是针对该中心的，这不是调查人员的机构。为了进一步定义慢性饮食维生素A的作用A。最近研究恒河猴A（VA）状态的最近工作（Macaca Mulatta）用作人类生物医学研究的模型，揭示了无毒的Hepatitic VA浓度。果猴猴（Callithrix jacchus）也显示出高VA水平和高血清视网膜酯浓度。这两种物种都均消耗了共同的研究饮食，这些饮食可提供是国家研究委员会推荐的VA量的四倍。对这些发现的进一步解释仅限于组织视黄醇和视网膜酯谱以及从其他物种中推断出来，而不是直接与正常值进行比较。为了进一步定义恒河猴中的VA状态，将雄性恒河猴用于涉及稳定同位素和肝活检的研究。虽然VA分析仍在进行过程中，但我们发现16个男性恒河猴（8至15岁）的化学筛选剖面中的异常值。在猴子中，其中包括升高的酒精磷酸酶，γ-谷氨酰胺转移，乳酸脱氢酶和天冬氨酸氨基转移酶。这些酶的升高引起了人们的关注，因为它们都是肝病或故障的标记，这是维生素A毒性的直接结果。这项研究使用了WNPRC研究服务。