Retrovial Infections of the Nervous System in Peru

秘鲁神经系统的逆行感染

基本信息

批准号：
7451055
负责人：
JOSEPH Raymond ZUNT
金额：
$ 56.55万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-10 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7451055
关键词：
AIDS neuropathy Acquired Immunodeficiency Syndrome Address Adult Blood Blood Banks Blood Donations Blood donor Blood donor screening Brain Brain Diseases CD4 Lymphocyte Count Capital Case Series Case-Control Studies Cell Count Central Nervous System Infections Childhood Cities Classification Clinic Clinical Clinical Investigator Clinical Research Cognitive Cohort Studies Collaborations Communicable Diseases Complement Contracts Counseling Country Dental Descriptive Epidemiology Development Diagnosis Diagnostic Enrollment Enzyme-Linked Immunosorbent Assay Faculty Family Study Female Foundations Funding Future General Population Goals Grant HIV HIV Infections HTLV Infection HTLV-II Infections Health Health Personnel Health Professional Hepatitis C Hepatitis C virus High Prevalence Human Subject Research Human T-lymphotropic virus 1 Human T-lymphotropic virus 2 Human immunodeficiency virus test Immune Incidence Infection Institutes Institution International AIDS Investigation Laboratories Letters Maintenance Malaria Measures Medical Medical Research Meningoencephalitis Mentors Morbidity - disease rate Natural History Nervous system structure Neurocysticercosis Neurologic Neurologic Examination Neurologic Manifestations Neurologist Neuropathy Neurosciences Neurosciences Research Numbers Other Finding Outcome Outcome Study Pathogenesis Pathology Patients Persons Peru Pneumonia Polymerase Chain Reaction Population Prevalence Principal Investigator Prospective Studies Public Health Public Health Informatics Rate Research Research Design Research Methodology Research Personnel Research Training Retroviridae Retrovirology Risk Risk Factors Ritual compulsion Screening procedure Sexual Partners Site Spinal Cord Diseases Symptoms Techniques Technology Transfer Testing Time Training Training Activity Training Programs Training and Education Tropical Medicine Trust United States United States National Institutes of Health Universities Viral Load result Viral load measurement Washington Western Blotting Work X-Ray Computed Tomography base case control clinical epidemiology clinical research site cohort design experience informatics training interest international center medical schools mortality nervous system infection pathogen programs protocol development rectal sex success symposium transmission process treatment trial virology

项目摘要

DESCRIPTION (provided by applicant): The overarching goals of this RO1 application are to study the clinical epidemiology and pathogenesis of retroviral, opportunistic and tropical infections of the nervous system in Peru, building on research collaborations and investigations initiated during the R21 grant entitled "Central Nervous System Infections in Peru"; and to continue development of neurologist investigators in academic and research institutions in selected cities throughout Peru. The specific aims of this grant are to 1) define the risk determinants and clinical manifestations of HTLV-II, HTLV-I, HIV infections and of coinfections with two or more of these three retroviral pathogens in the four largest cities in Peru; 2) establish a national reference center for clinical research on HTLV infection for conduct of cohort studies of the natural history, clinical manifestations, and pathogenesis of HTLV-I and -II infections in persons referred from blood banks; and 3) examine the influence of these three retroviral infections on the natural history of opportunistic and tropical infections of the CNS in persons with retroviral infection. During our R21 planning grant, we discovered that HTLV-II infection was unexpectedly prevalent in selected populations in Lima (the capital) and two of the largest cities in the Amazon Jungle. In addition, we developed research collaborations with neurologists in Lima (the capital), Iquitos (Jungle), Arequipa (Andes Mountains), and Trujillo (Coast), and determined the most common manifestations of neuroAIDS in Iquitos and Arequipa; and through conferences and in-country training, provided research and human subjects training to over 200 experienced and new clinical investigators - many of them neurologists. Concurrently, UW-led HIV/AIDS-related research funding in Peru has grown to $5,000,000 per year from NIH and from private foundations, providing an outstanding foundation for further development of a CNS retroviral research program. The Collaborative Network for Tropical Neurologic Infectious Diseases established with researchers in nongovernmental and Ministry of Health institutions in Peru, with the U.S. Naval Medical Research Center Detachment (NMRCD) in Peru, and with Universities in Peru and the United States, will support future research on the clinical epidemiology of retroviral infections and their interactions with emerging tropical infections in Peru and eventually the Andean Region. In addition to continuing our investigations, we plan to continue training activities to address the research, education, training, and mentoring needs and opportunities related to CNS infection identified during the R21 planning grant.

描述（由申请人提供）：本 RO1 申请的总体目标是研究秘鲁神经系统逆转录病毒、机会性和热带感染的临床流行病学和发病机制，以 R21 拨款期间发起的研究合作和调查为基础，题为“中央秘鲁的神经系统感染”；并继续在秘鲁各地选定城市的学术和研究机构培养神经学家研究人员。这笔赠款的具体目的是 1) 确定秘鲁四个最大城市中 HTLV-II、HTLV-I、HIV 感染以及这三种逆转录病毒病原体中两种或多种病原体合并感染的风险决定因素和临床表现； 2）建立国家HTLV感染临床研究参考中心，对血库转介人群HTLV-I和-II感染的自然史、临床表现和发病机制进行队列研究； 3) 检查这三种逆转录病毒感染对逆转录病毒感染者中枢神经系统机会性感染和热带感染自然史的影响。在我们的 R21 规划拨款期间，我们发现 HTLV-II 感染在利马（首都）和亚马逊丛林最大的两个城市的选定人群中出乎意料地流行。此外，我们与利马（首都）、伊基托斯（丛林）、阿雷基帕（安第斯山脉）和特鲁希略（海岸）的神经科医生开展了研究合作，并确定了伊基托斯和阿雷基帕最常见的神经艾滋病表现；通过会议和国内培训，为 200 多名经验丰富和新的临床研究人员（其中许多是神经科医生）提供研究和人类受试者培训。与此同时，威斯康星大学领导的秘鲁艾滋病毒/艾滋病相关研究经费已增加到每年 5,000,000 美元，来自 NIH 和私人基金会，为中枢神经系统逆转录病毒研究计划的进一步发展提供了良好的基础。与秘鲁非政府和卫生部机构的研究人员、秘鲁美国海军医学研究中心支队（NMRCD）以及秘鲁和美国的大学建立的热带神经传染病合作网络将支持未来的研究逆转录病毒感染的临床流行病学及其与秘鲁乃至安第斯地区新出现的热带感染的相互作用。除了继续我们的调查之外，我们还计划继续开展培训活动，以满足 R21 规划拨款期间确定的与中枢神经系统感染相关的研究、教育、培训和指导需求和机会。