Planning for avian influenza outbreaks and potential pandemic

禽流感爆发和潜在大流行的规划

• 批准号: 7231647
• 负责人: DONALD SCOTT BURKE
• 金额: $ 13.21万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-14 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7231647
• 关键词: Antiviral Agents; Avian Influenza; Birds; Communicable Diseases; Computer Simulation; Country; Depth; Detection; Disease; Disease Outbreaks; Distance Education; Educational workshop; Epidemic; Epidemiologic Studies; Epidemiologist; Epidemiology; Event; Faculty; Funding; Human; Infectious Disease Epidemiology; Influenza; International; Knowledge; Link; Measures; Methodology; National Institute of General Medical Sciences; Numbers; Population; Prevention; Public Health; Public Health Schools; Quarantine; Research; Research Personnel; Research Project Grants; Scientist; Silicon; Thailand; Time; Training; Training Programs; United States National Institutes of Health; Vaccines; Variant; computerized tools; experience; influenza outbreak; novel; pandemic disease; pandemic influenza; response; simulation; tool

DESCRIPTION (provided by applicant): This application to the Global Infectious Disease Training Program seeks to strengthen the epidemiologic research capacity for planning and response to emerging influenza outbreaks in Thailand. The detection of human cases of avian influenza in 2004 initiated concern both in Thailand and internationally that a new pandemic of influenza was about to begin. The depth of knowledge that has been gained over the last year about this emerging disease is illustrative of the strength of the research capabilities of Thai epidemiologists. However, the avian influenza experience has demonstrated the need to expand the number of scientists in Thailand with training in infectious disease epidemiology. Additionally, the scope of training required of epidemiologists to meet this new challenge exceeds existing training programs. Prevention of epidemics of newly emergent strains of influenza require national and international response. Epidemiologists must provide scientific input to planning and response in real-time. The proposed training would focus on methodologies that provide the most information to decision-makers during an incipient outbreak. Over the past several years, the Ministry of Public Health (MOPH) of Thailand and faculty at the Johns Hopkins Bloomberg School of Public Health have formed strong links on a variety of research projects on infectious diseases. Currently, investigators on this proposal are engaged in NIH (NIGMS) funded research to develop computational simulations of the spread of a novel variant of influenza in the Thai population should one emerge. Computational simulation provides an invaluable tool for conducting "epidemiology in silicon" to evaluate control measures such as the use of vaccines, antivirals, quarantine before an actual event. Functioning simulations could also provide real-time information on the course of epidemics and in evaluating changing requirements for control measures. The proposed training will develop the capacity for Thai epidemiologists to utilize new theoretical and computational tools in concert with traditional epidemiological approaches. The number of trainees proposed includes two MPH (each one year long) trainees at Johns Hopkins, 25 long-term in country trainees at the MOPH through the Field Epidemiology Training Program, and at least 50 short-term trainees through distance education and short-term in-country workshops.

描述（由申请人提供）：对全球传染病培训计划的申请旨在增强泰国新兴流感疫情的计划和反应的流行病学研究能力。 2004年对人类禽流感病例的检测引起了泰国和国际上的关注，并在国际上发现，流感的新大流行即将开始。去年，关于这种新兴疾病的知识深度说明了泰国流行病学家的研究能力的强度。但是，禽流感的经验表明，有必要通过传染病流行病学培训来扩大泰国的科学家人数。此外，要应对这一新挑战的流行病学家所需的培训范围超出了现有的培训计划。预防新出现的流感菌株流行病需要国家和国际反应。流行病学家必须实时提供计划和响应的科学意见。拟议的培训将集中于在初期爆发期间为决策者提供最多信息的方法。在过去的几年中，约翰·霍普金斯彭博公共卫生学院的泰国公共卫生部（MOPH）和教职员工在各种有关传染病的研究项目上建立了牢固的联系。目前，有关该提案的研究人员正在从事NIH（NIGMS）资助的研究，以开发有关泰国人口中新型流感变体传播的计算模拟。计算模拟为进行“硅流行病学”提供了一种宝贵的工具，以评估控制措施，例如在实际事件之前使用疫苗，抗病毒药，检疫。功能模拟还可以提供有关流行病过程以及评估控​​制措施不断变化的要求的实时信息。拟议的培训将使泰国流行病学家与传统流行病学方法一致利用新的理论和计算工具的能力。提议的学员人数包括约翰·霍普金斯（Johns Hopkins）的两个MPH（每年一年）学员，通过现场流行病学培训计划在MOPH的乡村学员中有25名长期的学员，以及通过远程教育和短期教育和短期内部工作坊至少50名短期学员。