Diffuse Optics for Acute Stroke Management

用于急性中风治疗的漫射光学器件

基本信息

批准号：
7524780
负责人：
ARJUN G. YODH
金额：
$ 55.42万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-15 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7524780
关键词：
Acute Address Affect Age Algorithms Analog-Digital Conversion Anatomy Animal Model Animals Anterior Antihypertensive Agents Attention Beds Biomedical Engineering Blood Blood Pressure Blood Vessels Blood flow Blood gas Bolus Infusion Brain Brain imaging Caring Cerebrospinal Fluid Cerebrovascular Circulation Cerebrovascular Disorders Cerebrovascular Physiology Cerebrum Clinic Clinical Clinical Data Clinical Management Clinical Research Clinical Trials Collaborations Condition Count Couples Data Detection Deterioration Development Device or Instrument Development Devices Diffuse Electronics Elements Engineering Exhibits Facility Construction Funding Category Family suidae Floor Future Generations Goals Head Hemoglobin Homeostasis Hospitalization Hour Human IV Fluid Image Infarction Intervention Ischemic Penumbra Ischemic Stroke Lasers Length Light Localized Location Logic Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Mathematics Measurement Measures Mediating Medical Metabolic Microspheres Middle Cerebral Artery Occlusion Modality Modeling Monitor Navigation System Nervous System Physiology Neurologic Noise Optical Instrument Optics Outcome Oxygen Patient Care Patients Pennsylvania Perfusion Perfusion Weighted MRI Pharmaceutical Preparations Phase Photons Physiologic Monitoring Physiological Pilot Projects Plasma Positioning Attribute Positron-Emission Tomography Predictive Value Procedures Property Public Health Rate Recovery Relative (related person)Reporting Research Research Personnel Role Sample Size Scheme Scientist Series Shapes Signal Transduction Simulate Source Spectrum Analysis Stroke Structure Structure of posterior cerebral artery Sus scrofa Symptoms Techniques Technology Technology Transfer Testing Thick Time Tissue Viability Tissues Today Tracer Translations United States Universities Validation acute stroke anterior cerebral artery attenuation base biomedical scientist blood perfusion brain tissue commercialization comparison group computerized data processing concept cost cranium day design detector disability hemodynamics heterodyning human data human subject improved indexing instrument instrumentation interest man medical complication medical specialties middle cerebral artery mortality novel pressure programs reconstruction research clinical testing respiratory gas response single photon emission computed tomography size theories tomography user friendly software validation studies volunteer

项目摘要

DESCRIPTION (provided by applicant): This Bioengineering Research Partnership (BRP) couples biomedical scientists & clinicians with expertise in cerebrovascular physiology and human stroke with biophysical scientists & engineers with expertise in optics, electronics, mathematics and computation. These partners will develop and validate a novel optical instrument for bedside monitoring of cerebral blood flow (CBF) and associated hemodynamics in acute stroke patients. Ischemic stroke is the leading cause of disability and a leading cause of mortality in the US today, affecting approximately 700,000 people annually with a projected cost of over $400 billion per decade. One of the major treatment challenges is the relative inaccessibility of brain tissue to physiological monitoring. Imaging modalities such as CT, MRI, and PET scanning require large and costly instrumentation that severely limit their use during patient hospitalization. Thus stroke interventions, intended to increase blood flow in and around the stroke region, are usually prescribed empirically or in response to clinical deterioration. Diffuse optics holds potential to dramatically change patient care by providing technology to measure CBF and associated hemodynamics continuously at the bedside, thereby permitting management interventions to be optimized and individualized for each patient based on tissue response. Preliminary data acquired in animal models and human subjects demonstrate the feasibility of this approach. Four research groups at the University of Pennsylvania will partner to further develop and validate this approach in the clinic. The Biomedical Optics Group led by P.I. Arjun Yodh will assume a central role participating in and coordinating project activities. Device development will be carried out in collaboration with the Electronic Instrumentation Group, led by Richard Van Berg. Validation in animal models will be carried out in collaboration with the Animal Studies Group, led by Joel Greenberg. Validation against MRI and SPECT blood flow measures in normal volunteers and in patients with acute stroke will be carried out in collaboration with the Clinical Studies Group, led by John Detre. Animal and human data will be used to guide refinements in instrument design and signal processing, and to develop sample size estimates for future clinical trials that will definitively demonstrate the efficacy of bedside CBF monitoring in stroke care. Technology commercialization and dissemination will be facilitated by Michael Cleare, Director of the Center for Technology Transfer. Diffuse Optics for Acute Stroke Management. PUBLIC HEALTH RELEVANCE: Ischemic stroke is the leading cause of disability and a leading cause of mortality in the United States today. There is no technique for monitoring blood flow in the brain of stroke victims in the hours and days following their stroke. The goal of this project is to develop and validate an instrument for monitoring blood flow and oxygenation in the brain of acute stroke patients at the bedside prior to the onset of new symptoms so as to facilitate their clinical management.

描述（由申请人提供）：这种生物工程研究伙伴关系（BRP）夫妇生物医学科学家和临床医生在脑血管生理学方面具有专业知识，并与生物物理学科学家和工程师具有光学，电子，数学和计算方面的专业知识。这些伴侣将开发并验证一种新型的光学仪器，用于急性中风患者的脑血流（CBF）和相关血流动力学的床边监测。缺血性中风是当今美国残疾的主要原因，也是死亡率的主要原因，每年约有70万人每十年的成本超过4000亿美元。主要的治疗挑战之一是脑组织与生理监测的相对无法访问。 CT，MRI和PET扫描等成像方式需要大量且昂贵的仪器，这在患者住院期间严重限制了其使用。因此，旨在增加中风区域内和周围血液流量的中风干预通常是经验上的或响应临床恶化的。通过提供技术在床边连续测量CBF和相关的血液动力学，弥漫性光学器件具有显着改变患者护理的潜力，从而允许根据组织反应为每个患者进行优化和个性化管理干预措施。在动物模型和人类受试者中获得的初步数据证明了这种方法的可行性。宾夕法尼亚大学的四个研究小组将在诊所中进一步发展和验证这种方法。 P.I.领导的生物医学光学组Arjun Yodh将担任参与和协调项目活动的核心角色。设备开发将与理查德·范·伯格（Richard Van Berg）领导的电子仪器集团合作进行。动物模型的验证将与乔尔·格林伯格（Joel Greenberg）领导的动物研究小组合作进行。对正常志愿者和急性中风患者的MRI和SPECT血液流量测量的验证将与约翰·迪特雷（John Detre）领导的临床研究小组合作进行。动物和人类数据将用于指导仪器设计和信号处理中的改进，并为将来的临床试验开发样本量估计，这些试验将确定证明床边CBF监测在中风护理中的功效。技术转移中心主任Michael Cleare将促进技术商业化和传播。用于急性中风管理的漫射光学器件。公共卫生相关性：缺血性中风是当今美国残疾的主要原因和死亡的主要原因。在中风后的几个小时和几天内，没有一种技术来监测中风受害者大脑的血流。该项目的目的是在新症状发作之前开发和验证一种用于监测床边急性中风患者大脑的血流和氧合的工具，以促进其临床治疗。