DEVELOPMENT OF DIFFUSE OPTICS FOR BREAST CANCER IMAGING AND MONITORING

用于乳腺癌成像和监测的漫射光学器件的开发

• 批准号: 8361960
• 负责人: ARJUN G. YODH
• 金额: $ 3.84万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361960
• 关键词: Area; Blood; Blood Vessels; Breast; Cell Nucleus; Contrast Media; Death Rate; Development; Diagnosis; Diffuse; Fluorescence; Funding; Generations; Grant; Hemoglobin; Light; Lipids; Magnetic Resonance; Malignant Neoplasms; Mammary Neoplasms; Medicine; Metabolic; Methods; Mitochondria; Monitor; National Center for Research Resources; Nonionizing Radiation; Optical Methods; Optics; Organelles; Oxygen; Perfusion; Population; Principal Investigator; Process; Property; Research; Research Infrastructure; Resources; Screening procedure; Sensitivity and Specificity; Source; Spectrum Analysis; Tissues; United States National Institutes of Health; Veins; Water; Woman; absorption; base; cancer imaging; cost; malignant breast neoplasm; minimally invasive; molecular imaging; optical imaging; tool; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Breast cancer is one of the most common cancers among women worldwide. To lower the death rate due to breast cancer, significant improvements in the areas of screening, diagnosis, and therapy monitoring of cancer are imperative. Diffuse optical imaging and spectroscopy methods promise new tools for these applications. The optical methods utilize non-ionizing radiation (e.g. red to infrared light), are non-invasive or minimally-invasive, are inexpensive, technologically simple and fast. These methods provide several unique parameters based on functional processes in tissues with potential to enhance breast tumor sensitivity and specificity. Tissue optical absorption coefficients provide access to blood dynamics, total hemoglobin concentration, blood oxygen saturation, water concentration and lipid content. These tissue properties are often substantially different in rapidly growing tumors; for example, high concentrations of hemoglobin with low oxygen saturation are suggestive of rapidly growing tumors due to their high metabolic demand and (sometimes) poor perfusion. In a different vein, an increase in organelle population, particularly mitochondria or nuclei, sometimes accompanies the higher metabolic activity of the rapidly growing tumor, and leads to an increase of optical scattering coefficients for the tumor. Finally, optical absorption, fluorescence, and scattering of exogenous contrast agents that occupy vascular and extravascular space also provide useful forms of sensitization. Along these lines, advances in diffuse optical imaging of breast are critical for exploitation of advances in the field of Molecular Imaging, an emerging area of medicine promising development of new generation contrast agents.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 乳腺癌是全球女性中最常见的癌症之一。降低死亡 乳腺癌引起的速度，筛查，诊断领域的显着改善和 癌症的治疗监测必须进行。弥漫性光学成像和光谱法 向这些应用程序保证新工具。光学方法利用非电离辐射 （例如，红色到红外光），无创或微不足道，在技术上很便宜 简单快捷。这些方法基于功能过程提供了几个独特的参数 在具有增强乳腺肿瘤敏感性和特异性的潜力的组织中。 组织光学 吸收系数可提供血液动力学，总血红蛋白浓度，血液 氧饱和度，水浓度和脂质含量。这些组织特性通常是 在快速生长的肿瘤中有根本不同的；例如，高浓度的血红蛋白 氧饱和度低的暗示着由于其高代谢而迅速生长的肿瘤 需求和（有时）灌注不良。不同的是，细胞器种群的增加， 特别是线粒体或核，有时会伴随着较高的代谢活性 快速生长的肿瘤，并导致肿瘤的光学散射系数增加。 最后，光吸收，荧光和占用的外源性对比剂的散射 血管和血管外空间还提供了有用的敏化形式。沿着这些线 乳腺弥漫性光学成像的进步对于在该领域的进步剥削至关重要 分子成像，一个新兴的医学领域，有望发展新一代 对比剂。