BED-SIDE MONITORING OF TRAUMATIC BRAIN INJURY AND STROKE

创伤性脑损伤和中风的床边监测

• 批准号: 7955328
• 负责人: ARJUN G. YODH
• 金额: $ 1.67万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955328
• 关键词: Beds; Brain Part; Cerebrovascular Circulation; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Devices; Diffuse; Funding; Grant; Head; Homeostasis; Hybrids; Hyperoxia; Institution; Ischemia; Magnetic Resonance; Measures; Monitor; Optics; Oxyhemoglobin; Patients; Positioning Attribute; Research; Research Personnel; Resources; Risk; Side; Source; Stroke; Subarachnoid Hemorrhage; Techniques; Traumatic Brain Injury; United States National Institutes of Health; hemodynamics; injured; optical imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For patients who have suffered neurotrauma due to traumatic brain injury (TBI) or subarachnoid hemorrhage (SAH), it is of utmost importance to monitor changes in their cerebral blood flow (CBF) and oxygenation due to risk of ischemia in injured parts of the brain. In this study, we used a hybrid diffuse optical device to characterize the hemodynamic effects of head position and hyperoxia on neurotrauma patients, thereby assessing their cerebral autoregulation. The device is being developed as a portable, relatively inexpensive bedside monitor that employs non-invasive, continuous optical techniques to measure changes in CBF as well as deoxy- and oxyhemoglobin concentrations.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 对于因脑损伤（TBI）或蛛网膜下腔而导致神经瘤的患者 出血（SAH），监测其脑血流的变化至关重要 （CBF）和由于大脑受伤部分缺血的风险而导致的氧合。在这项研究中，我们使用了 一种混合弥漫性光学设备，以表征头部位置的血液动力学作用和 神经肿瘤患者的高氧，从而评估其脑自动调节。设备 正在开发为一种便携式，相对便宜的床旁监视器，该监视器采用了无创， 连续的光学技术，用于测量CBF以及脱氧和氧气的变化 浓度。