GAMMACELL-220 EXCEL REFURBISHED RESEARCH IRRADIATOR: BIODEFENSE

GAMMACELL-220 EXCEL 翻新研究辐照器：生物防御

• 批准号: 7335187
• 负责人: DAVID H WALKER
• 金额: $ 10.64万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7335187
• 关键词: biomedical facility; bioterrorism /chemical warfare; communicable diseases; community; hyperthermia; infection; proteomics; success; university

This subproject is one of many research subprojects utilizing the resources provided by a Shared Instrumentation Grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the grant, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): Over the past two decades, the University of Texas Medical Branch at Galveston (UTMB) has built a premier infectious disease research program focused on emerging infections and biodefense pathogens in accordance with the NIAID's mission to develop countermeasures for these agents. This success is largely due to a critical mass of world-class researchers and the availability of unique laboratory facilities. In 2003, UTMB was the only academic institution awarded NIAID grants to establish both a Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research and a National Biocontainment Laboratory (NBL) to provide more high containment laboratory space. In addition, with partial support from the NIAID, a toiosafety level 4 (BSL4) laboratory was opened in 2003 (and became operational in 2004) as the first laboratory of its type on a university campus in North America. These facilities provide an opportunity to increase overall research efforts, including the capability to conduct studies on the world's most dangerous pathogens. A critical requirement inherent to the scope of the NIAID's research mission is to share these facilities with regional and national researchers and to provide support services for research that can only be done in these high containment facilities. A reliable biosafety and biosecurity method is essential for sharing and working safely with the highly dangerous agents. Therefore, the overall objective is to procure a Gammacell 220 Excel refurbished research irradiator to provide the most reproducible and controlled method to inactivate these dangerous agents while at the same time preserving their biological properties. An example of use of this instrument will be to inactivate Rift Valley fever virus such that genomic and proteomics analysis can be safely performed outside the BSL4 laboratory. The irradiator will be available for use by NIH-supported UTMB investigators, as well as NIH-supported regional and national investigators. When the NBL is completed in 2008, researchers from that facility will also have access to the irradiator. A representative users' group with 21 funded grants are described, including 14 major (12 of which are NIH- funded) and 7 minor users representing multidisciplinary research projects involving several departments at UTMB. It is important to note that usage of the proposed gamma irradiator will drastically increase as usage of the BSL4 laboratory increases and with the completion of the NBL. The irradiator will be maintained and operated under an advisory oversight committee as a core facility in the Center for Biodefense and Emerging Infectious Diseases at UTMB. Yearly maintenance fees will be charged to Pis and administered through the BSL4 Service Center. The irradiator will significantly enhance the ability of investigators to conduct research safely and more efficiently, as well as protect the community from any threats that may be associated with working with these life-threatening pathogens.

该副本是利用NIH/NCRR资助的共享仪器赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是赠款，这不一定是调查人员的机构。描述（由申请人提供）：在过去的二十年中，加尔维斯顿大学（UTMB）的德克萨斯大学医学分支机构建立了一项主要的传染病研究计划，着重于新兴感染和生物脱发病原体，并根据NIAID的使命开发这些疾病的使命。代理商。这一成功在很大程度上是由于世界一流的研究人员以及独特的实验室设施的可用性。 2003年，UTMB是唯一一家授予NIAID赠款的学术机构，既可以建立一个地区生物化卓越和新兴的传染病研究中心，又是国家生物培养实验室（NBL）提供更高的容器实验室空间。此外，在NIAID的部分支持下，2003年开设了Toiosafety Level 4（BSL4）实验室（并于2004年开始运营），作为该类型的第一个实验室，该实验室在北美的大学校园中。这些设施提供了增加整体研究工作的机会，包括对世界上最危险的病原体进行研究的能力。 NIAID研究任务范围固有的关键要求是与区域和国家研究人员共享这些设施，并为研究提供支持服务，只能在这些高遏制设施中进行。可靠的生物安全和生物安全方法对于与高度危险的代理人共享和合作至关重要。因此，总体目标是采购Gammacell 220 Excel翻新研究辐照器，以提供最可重复和受控的方法，以使这些危险药物失活，同时保留其生物学特性。使用该仪器的一个例子是使裂谷谷热病毒失活，以便可以在BSL4实验室外安全地进行基因组和蛋白质组学分析。 NIH支持的UTMB调查人员以及NIH支持的区域和国家调查员将使用辐照机。当NBL于2008年完成时，该设施的研究人员也将可以使用辐照器。描述了一个具有21个资助赠款的代表用户组，其中包括14个主要（其中12个由NIH资助）和7个代表涉及UTMB多个部门的多学科研究项目的次要用户。重要的是要注意，随着BSL4实验室的使用增加并随着NBL的完成，对拟议的伽玛辐照器的使用将大大增加。辐照机将在咨询监督委员会的咨询委员会下进行维护和运营，作为UTMB生物延伸和新兴传染病中心的核心设施。年度维护费将向PI收取，并通过BSL4服务中心进行管理。辐照机将显着增强研究人员安全地进行研究的能力，并保护社区免受与这些威胁生命的病原体有关的威胁。