EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROJECTS

校外研究设施改进项目

• 批准号: 6720432
• 负责人: ARTHUR H., M.B.B.CH. RUBENSTEIN
• 金额: $ 400万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6720432
• 关键词: animal colony; biomedical facility; bioterrorism /chemical warfare; building /facility design /renovation; communicable diseases; genetics; laboratory mouse; stem cells; university

DESCRIPTION (provided by applicant): The University of Pennsylvania (UPenn) School of Medicine is one of the nations premier biomedical research institutions. Funding from the National Institutes of Health (NIH) alone totaled $347 million in FY2002, which ranks second among all academic medical centers. Growth in UPenn's sponsored research was nearly 200 percent during the past decade. As much of this work is dependent upon rodent systems and models, the murine colony expanded at nearly 20 percent annually during this time. Thus despite aggressive facility expansion, current animal housing capacity is nearly saturated, and funded or planned research activities are in jeopardy. In view of these facts, funds are requested to build a state-of-the-art rodent barrier facility within a funded new research building to be jointly occupied by faculty from the School of Medicine and the School of Veterinary Medicine. This rodent barrier facility will have a capacity of approximately 10,000 small mouse cages. The thematic scope of this project will be to support three areas of active research that receive significant NIH funding. They are Stem Cell Biology, Infectious Disease and Bioterrorism, and Genetics. A new rodent barrier facility to support these themes of research will consolidate this research for greater collaborative work among investigators and increased resource efficiencies while significantly decreasing overcrowded conditions experienced in other rodent facilities on campus. The School of Medicine is committed to maintaining full accreditation with AAALAC International. This facility will meet AAALAC standards, improve the quality and quantity of rodent housing, and more adequately meet the needs of NIH-funded research.

描述（由申请人提供）： 宾夕法尼亚大学（UPENN）医学院是国家首屈一指的生物医学研究机构之一。 仅国立卫生研究院（NIH）的资金在2002财年总计3.47亿美元，在所有学术医疗中心中排名第二。 在过去的十年中，Upenn赞助的研究的增长近200％。 由于这项工作的大部分取决于啮齿动物的系统和模型，因此在此期间，鼠殖民地每年以近20％的速度扩展。 因此，尽管设施的扩大，但当前的动物住房能力几乎饱和，资助或计划的研究活动仍处于危险之中。 鉴于这些事实，要求资金在一座资助的新研究大楼内建立最先进的啮齿动物障碍设施，该研究大楼将由医学院和兽医学院的教职员工共同占用。 该啮齿动物屏障设施的容量约为10,000个小鼠笼子。 该项目的主题范围将是支持获得大量NIH资金的三个积极研究领域。 它们是干细胞生物学，传染病和生物恐怖主义以及遗传学。 一个新的啮齿动物障碍设施来支持这些研究主题，将巩固这项研究，以在研究人员之间进行更大的合作工作和提高资源效率，同时大大降低了校园其他啮齿动物设施中经历的过度拥挤状况。 医学院致力于维持AAAALAC国际的全面认证。该设施将符合AAALAC标准，提高啮齿动物住房的质量和数量，并更充分地满足NIH资助的研究的需求。