Acquisition of a 7T human MR system for the development of ultra high resolution

购置7T人体MR系统，用于开发超高分辨率

• 批准号: 7127961
• 负责人: Douglas Lyle Rothman
• 金额: $ 200万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7127961
• 关键词: brain; clinical research; epilepsy; hand; human; learning disorders; technology /technique development

DESCRIPTION (provided by applicant): The development of MR technology has allowed biomedical researchers to make major advances in understanding and treating human disease among the major areas of strength in our MR program are applications to diabetes, epilepsy and image guided surgery, psychiatric disease, and learning disorders. Our progress in these areas has gone hand in hand with the development of MR technology focused on obtaining quantitative images of metabolic fluxes and metabolite levels, and quantitative fMRI measures of blood flow, blood volume and metabolism. All of these measurements put extreme demands on MR sensitivity and spatial resolution. At present the highest resolution and sensitivity achievable in humans is from 7T systems. Based on published studies a 3 fold sensitivity in MRSI and a similar enhancement for quantitative fMRI measures can be achieved. However the application of 7T MR to clinical research has been restricted due to the inability, primarily as a consequence of the increased Bo inhomogeneity, to obtain whole brain distortion free MRSI and fMRI. For example applications of MR to epilepsy, neurodegenerative diseases, and image guided neurosurgical planning requires high quality MRSI and fMRI in regions near the base of the brain such as the hippocampus, where the worst Bo inhomogeneity is present. At present none of the existing 7T systems have presented adequate quality MRS or fMRI in these regions for research purposes much less surgical applications. We feel strongly, based upon our extensive experience developing and applying MR technology to important questions in clinical research, that the several fold higher sensitivity made possible by 7T magnet technology has the potential of greatly advancing the field. Therefore the major goals of this project are to 1) purchase and install a Varian/Magnex 7T 68 system with gradients and shims optimized for whole brain dynamic shimming, 2) develop quantitative whole brain and limb ultra high resolution MRSI and fMRI using dynamic shim updating, Bo and B1 robust pulse sequences, and parallel imaging approaches and 3) apply this technology to allow the programs at Yale in diabetes, epilepsy and image guided neurosurgery, psychiatry, and learning disorders to continue to make important strides in the understanding and treatment of human disease.

描述（由申请人提供）：MR技术的发展使生物医学研究人员能够在我们的MR计划的主要优势领域中理解和治疗人类疾病的重大进展是对糖尿病，癫痫和图像指导性手术，精神病和学习障碍的申请。我们在这些领域的进步与MR技术的发展息息相关，这些MR技术着重于获得代谢通量和代谢物水平的定量图像，以及血液流量，血容量和代谢的定量fMRI测量。所有这些测量值对MR敏感性和空间分辨率提出了极大的要求。目前，人类可以实现的最高分辨率和灵敏度来自7T系统。根据已发表的研究，MRSI的3倍灵敏度，可以实现定量fMRI措施的类似增强。但是，由于无法增加BO不均匀性，因此，由于无法获得全脑失真的MRSI和fMRI，因此由于无法增加，将7T MR应用于临床研究已受到限制。例如，在癫痫，神经退行性疾病和图像引导的神经外科计划中的应用需要高质量的MRSI和fMRI在大脑底部附近的区域，例如海马，那里存在最坏的BO INHAPPOCAMEN。目前，现有的7T系统都没有在这些地区提供足够的质量MRS或fMRI，用于研究目的要少得多。基于我们在临床研究中的重要问题中开发和应用MR技术的丰富经验，我们感到非常强烈，以至于7T磁铁技术使几个更高的敏感性成为可能，从而有可能大大推进该领域。因此，该项目的主要目标是1）购买并安装具有针对全脑动态动态的梯度和垫片进行优化的Varian/Magnex 7T 68系统，2）2）使用动态的SHIM更新，将BO和B1的EPET应用于AD -EPER，并允许在Image和3的图像中使用动态的SHIM更新，并将其应用于该技术，并允许使用该技术，并将其图像适用，并允许使用动态的整个大脑和Limb超高分辨率MRSI和FMRI。指导神经外科，精神病学和学习障碍，以继续在理解和治疗人类疾病方面取得了重要成就。