Development of an Intervention for Palauan Youth at Genetic Risk for Psychosis

为有精神病遗传风险的帕劳青少年制定干预措施

• 批准号: 7232467
• 负责人: PAUL W FLORSHEIM
• 金额: $ 14.18万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7232467
• 关键词: Address; Adolescence; Adolescent; Behavioral; Clinical; Collaborations; Communities; Coping Skills; Data; Data Set; Developed Countries; Developing Countries; Development; Disease; Education; Educational workshop; Effectiveness; Environmental Risk Factor; Funding; Genetic; Genetic Predisposition to Disease; Genetic Risk; Goals; Government; Grant; Health; Health Personnel; Health Professional; Health system; Identification (Psychology); Individual; International; Intervention; Intervention Studies; Island; Lead; Life; Medical; Mental Health; Mission; Modeling; National Institute of Mental Health; Nurses; Onset of illness; Palau; Paper; Physicians; Pilot Projects; Population; Prevention program; Preventive Intervention; Psychologist; Psychology; Psychopathology; Psychotic Disorders; Public Health; Range; Research; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Sampling; Schizophrenia; Science; Social Workers; Societies; Students; Supervision; Symptoms; Testing; Time; Training; Training Programs; Translating; Travel; Universities; Utah; Work; Youth; base; college; design; international center; intervention program; next generation; programs; protocol development; psychologic; resilience; skills; stressor; symposium; therapy design; therapy development

DESCRIPTION (provided by applicant): Researchers have proposed that both genetic and environmental factors can contribute to the development of psychosis during adolescence and young adulthood. Individuals identified as being at high genetic risk for schizophrenia may not develop the disorder if they possess skills for coping with initial symptoms and reducing associated stressors. Understanding how to facilitate resilience and support protective factors among adolescents at risk for schizophrenia has implications for many individuals and communities because schizophrenia occurs across societies. Developing preventive-intervention models for schizophrenia is particularly important for regions of the world where the genetic risk for schizophrenia is particularly high and the medical resources for managing the illness are scarce. For example, the Republic of Palau is an isolated island nation with a population at heightened risk for schizophrenia and other psychotic disorders (Myles- Worsley et al., 1999). This population provides an excellent opportunity for testing preventive-intervention models because (a) the genetic risk status of individuals has been previously identified and (b) the government of Palau is eager to develop nonstigmatizing strategies to address the problem. The goals of the proposed project are to build capacity among Palauan health care providers to conduct intervention research and to pilot an existing preventive-intervention program for the first time among Palauan adolescents at-risk for psychotic disorders. The first year of the project would involve research training workshops, a clinical training workshop, and a workshop in culturally sensitive protocol development. The second year would involve pilot testing a Palauan-adapted preventive-intervention program on a small sample of high-risk youth (n=30). The training component of the grant is designed for Palauan health care providers and will utilize datasets previously collected from Palauan adolescents at-risk for psychotic disorders (Myles-Worsley et al., 1999). This project represents an international collaboration between psychologists and physicians with a wide range of expertise (e.g. preventive-intervention, adolescent treatment, public health, research education, schizophrenia and psychosis). The long-term goal of the project is to build research capacity in a developing nation and to test strategies for conducting a large scale preventive-intervention study targeting adolescents at heightened risk for psychosis, living in isolated regions of the world.

描述（由申请人提供）：研究人员提出，遗传和环境因素都可能导致青春期和成年早期精神病的发展。被确定为精神分裂症高遗传风险的个体，如果他们具备应对初始症状和减少相关压力源的技能，可能不会患上这种疾病。了解如何促进有精神分裂症风险的青少年的恢复能力和支持保护因素对许多个人和社区都有影响，因为精神分裂症发生在整个社会。对于世界上精神分裂症遗传风险特别高且治疗该疾病的医疗资源稀缺的地区来说，开发精神分裂症的预防干预模型尤为重要。例如，帕劳共和国是一个孤立的岛国，其人口患精神分裂症和其他精神病的风险很高（Myles-Worsley 等，1999）。该人群为测试预防性干预模型提供了绝佳的机会，因为（a）个体的遗传风险状况先前已被确定，并且（b）帕劳政府渴望制定非污名化策略来解决该问题。拟议项目的目标是建设帕劳医疗保健提供者进行干预研究的能力，并首次在有精神障碍风险的帕劳青少年中试点现有的预防性干预计划。该项目的第一年将包括研究培训研讨会、临床培训研讨会和文化敏感方案开发研讨会。第二年将针对一小部分高危青少年（n = 30）对适应帕劳的预防干预计划进行试点测试。该赠款的培训部分是为帕劳医疗保健提供者设计的，并将利用以前从有精神病风险的帕劳青少年收集的数据集（Myles-Worsley 等，1999）。该项目代表了具有广泛专业知识（例如预防干预、青少年治疗、公共卫生、研究教育、精神分裂症和精神病）的心理学家和医生之间的国际合作。该项目的长期目标是建设发展中国家的研究能力，并测试针对生活在世界偏远地区的精神病高危青少年进行大规模预防性干预研究的策略。

项目成果

Early signs and symptoms of psychosis among Palauan adolescents.

帕劳青少年精神病的早期体征和症状。

• DOI: 10.1111/j.1751-7893.2010.00164.x
• 发表时间: 2010
• 期刊: Early intervention in psychiatry
• 影响因子: 2
• 作者: Madraisau,Sheri;Tomoichi,Ulai;Ord,LisaM;Florsheim,Paul;Phillips,LisaJ;Blailes,Francisca;Basilius,Merlyn;Kuartei,Stevenson;Tiobech,Josepha;Myles-Worsley,Marina;Ngiralmau,Hilda
• 通讯作者: Ngiralmau,Hilda

Adoption, family relations and psychotic symptoms among Palauan adolescents who are genetically at risk for developing schizophrenia.

有患精神分裂症遗传风险的帕劳青少年的收养、家庭关系和精神病症状。

• DOI: 10.1007/s00127-009-0154-x
• 发表时间: 2010
• 期刊: Social psychiatry and psychiatric epidemiology
• 影响因子: 4.4
• 作者: Ierago,Laura;Malsol,Cynthia;Singeo,Techong;Kishigawa,Yuri;Blailes,Francisca;Ord,Lisa;Florsheim,Paul;Phillips,Lisa;Kuartei,Stevenson;Tiobech,Josepha;Watson,Berrymoon;Ngiralmau,Hilda
• 通讯作者: Ngiralmau,Hilda