Portable Analyzer for On-site Monitoring of Worker Exposure to Toxic Metals

用于现场监测工人接触有毒金属的便携式分析仪

• 批准号: 7282746
• 负责人: CHARLES TIMCHALK
• 金额: $ 20.02万
• 依托单位: BATTELLE PACIFIC NORTHWEST LABORATORIES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7282746
• 关键词: Portable; Analyzer; site; Monitoring; Worker

DESCRIPTION (provided by applicant): Large numbers of industrial workers are regularly exposed to toxic heavy metals like cadmium (Cd), lead (Pb), and mercury (Hg), which are known to induce various diseases that are detrimental to human health. In order to monitor workers for multiple toxic metal exposures and to ensure that these exposures are below a threshold for inducing permanent damage to various organ systems, a portable analyzer for real-time, onsite, non-invasive monitoring of workers for toxic metal exposure will be developed using a novel approach developed by our research group at the Pacific Northwest National Laboratory (PNNL). The analyzer will be based on the built-in preconcentration of cadmium, lead, and mercury present in urine by the highly efficient sorbent materials, created at PNNL, prior to their voltammetric quantitation. Urine is universally recognized as one of the best non-invasive matrix to assess both acute and ongoing exposures to a broad range of many toxic metals. The sorbent materials are the marriage of self-assembled functionalization and extremely high surface area silia and are designed to be highly specific for the metal ions even in 1) complex urine matrix, 2) urine with elevated level of proteins resulting from renal diseases, and 3) urine with elevated level of metal-chelates resulting from chelation administration. Thus our sensors do not require toxic mercury for metal ion preconcentration unlike conventional electrochemical sensors. Delivery of samples and reagents will be based on programmable sequential injection with turbulent flow-onto a design that minimizes the sensor fouling caused by proteins. The analyzer will reduce the time and costs of monitoring worker exposure and clinical diagnosis. It represents the next-generation of metal ion analyzer because of its affordability, low power consumption, portability, full automation, and easy operation, which are better than the traditional analytical methods like AAS and ICP-MS. This project directly responds to PA-04-030 of NIOSH/R21 for the development of research tools and approaches for exposure assessment. The portable analyzer will enable (1) better identification of at-risk workers and development of appropriate control and intervention strategies, (2) understanding of exposure-response relationships, and (3) improvement of baseline data for a standard setting and risk assessment, all of which have been identified as important by the Exposure Assessment Methods (EAM) team commissioned by NIOSH's National Occupational Research Agenda (NORA). Once successful, the portable analyzer can be easily extended to the analysis of other toxic metal ions such as chromium, arsenic, lanthanides, and actinides by using combination of other sorbent materials that have already been created to be specific for the sorption of such analytes. Ultimately, the sensor for metal ions will be combined with the sensor for creatinine so that the exposure monitoring can be performed with "spot" urine instead of 24-hr urine.

描述（由申请人提供）：大量工业工人经常暴露于诸如镉（CD），Lead（PB）和汞（HG）等有毒重金属中，这些工人已知会诱发各种对人类健康有害的疾病。为了监测工人的多种有毒金属暴露，并确保这些暴露量低于对各种器官系统造成永久损害的阈值，这是一种实时，现场，现场，非侵入性监测毒性金属暴露的可移植分析仪，使用我们的新型研究小组开发的Norkes National National National National Laboratoration（PNNL）开发了一种新颖的方法。该分析仪将基于在PNNL上产生的高效吸附材料在尿液中，在其伏安定量之前，尿液中的镉，铅和汞的内置预浓缩。尿液被普遍认为是评估许多有毒金属范围的急性和持续暴露的最佳非侵入性基质之一。吸附的材料是自组装功能化和极高的表面积硅藻的结合，即使在1）复杂的尿液基质中也对金属离子高度具体，2）尿液含量升高，导致肾脏疾病升高，3）尿液升高，导致螯合剂升高的尿液水平升高。因此，与常规电化学传感器不同，我们的传感器不需要金属离子预浓缩。样品和试剂的递送将基于可编程顺序注入，湍流的设计最小化蛋白质引起的传感器污染。分析仪将减少监测工人接触和临床诊断的时间和成本。它代表了金属离子分析仪的下一代，因为它的负担能力，低功耗，便携性，完整的自动化和易于操作，它们比AAS和ICP-MS（例如AAS和ICP-MS）更好。该项目直接响应了NIOSH/R21的PA-04-030，以开发研究工具和暴露评估方法。便携式分析仪将使（1）更好地识别高危工人，并开发适当的控制和干预策略，（2）了解暴露 - 响应关系，以及（3）改进标准设置和风险评估的基线数据，以确定所有这些都被Niosh Niosh Nieosh国家占领研究的Agnational Issitational Issitation Arga Agna（Nora）所委托的曝光评估方法（EAM）所确定的所有这些都很重要。一旦成功，便携式分析仪可以轻松地扩展到对其他有毒金属离子（例如铬，砷，灯笼和肌动剂）的分析，并通过使用已经创建的其他吸附材料的组合，这些材料特定于吸附此类分析物。最终，金属离子的传感器将与肌酐的传感器结合使用，以便可以使用“斑点”尿液而不是24小时的尿液进行曝光监测。

项目成果

Detection of Cd, Pb, and Cu in non-pretreated natural waters and urine with thiol functionalized mesoporous silica and Nafion composite electrodes.

• DOI: 10.1016/j.aca.2008.05.029
• 发表时间: 2008-07
• 期刊: Analytica chimica acta
• 影响因子: 6.2
• 作者: W. Yantasee;Busarakum Charnhattakorn;G. Fryxell;Yuehe Lin;C. Timchalk;R. Addleman