Non-invasive cardio-pulmonary monitor for mice

小鼠无创心肺监护仪

基本信息

批准号：
7286297
负责人：
MARTIN Carl BARUCH
金额：
$ 36.47万
依托单位：
EMPIRICAL TECHNOLOGIES CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-01-01 至 2009-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7286297
关键词：
Adult Affect Age Agreement Algorithms Ambulatory Blood Pressure Monitoring Anesthetics Animal Experimentation Animal Model Animals Antigens Asthma Biological Rhythm Blood Pressure Blood Pressure Monitors Blood Vessels CD4 Positive T Lymphocytes Cardiac Cardiopulmonary Catheters Cell physiology Chest Clinical Computer software Computers Congestive Heart Failure Consumption Custom Dendritic Cells Development Devices Disclosure Disease Distributed Systems Electrocardiogram Electrodes Engineering Equipment Exhibits Frequencies Functional disorder GIRK4 subunit, G protein-coupled inwardly-rectifying potassium channel GTP-Binding Proteins General Anesthesia Genetic Genetic Engineering Head Health Heart Atrium Heart Block Heart Rate Hour Inherited Injection of therapeutic agent Invasive Investigation Laboratories Lead Left Letters Longitudinal Studies Lung Manufacturer Name Marketing Measurement Measures Medical Memory Methods Miniaturization Modeling Modification Molecular Monitor Mouse Strains Movement Mus Myocardial Infarction Myotonic Dystrophy Neuromuscular Diseases Newborn Infant None or Not Applicable Numbers Operative Surgical Procedures Patients Pattern Peer Review Performance Phase Physiologic Monitoring Physiologic pulse Physiological Population Potassium Channel Predisposition Publications Pulse taking Radio Rate Records Research Research Personnel Respiration Rivers Sepsis Services Signal Transduction Site Skin Standards of Weights and Measures Stress Tests System T-Cell Receptor T-Lymphocyte Techniques Technology Testing Tetracycline Tetracyclines Time Transgenic Mice Transgenic Organisms Universities Validation Variant Virginia Week Wild Type Mouse Wireless Technology atrioventricular node base computerized data processing day design drug testing gene therapy genetic manipulation graphical user interface implantation interest methacholine millisecond miniaturize mouse model outcome forecast physical state receptor research and development respiratory response sensor size subcutaneous systems research transmission process

项目摘要

DESCRIPTION (provided by applicant): The results of the Phase I effort, during the course of which the physiological signals of eight mice were determined and correlated with established "golden standard" techniques, have demonstrated the feasibility of monitoring and identifying clearly distinguishable physiological signals by measuring the mouse's chest movements with a saddle-type sensor. More importantly, the results clearly established that this sensor can answer the need for the long-term and continuous monitoring of mobile mice, particularly those animals whose state of health is so precarious as a result of genetic intervention and age that invasive monitoring means are not an option. As part of the Phase II effort the system will be miniaturized so that the entire sensing assembly can be moved onto the mouse and a miniature wireless transmission system will be integrated into the sensor system. The real-time signal processing algorithms will be optimized and a computer-based graphical user interface (GUI) completed. In order to validate the performance of the sensing system, two studies will be performed at the University of Virginia on mouse populations whose fragile state of health does not permit invasive monitoring. One study will involve mice with inducible myotonic dystrophy, while the other will study asthmatic mice. An alliance has been formed with a well-known manufacturer of physiological monitoring equipment to commercialize the product. The need for the long-term monitoring of cardiopulmonary rhythms in mice is growing along with an increasing population of mice strains that are being used to test drug responses, genetic engineering attempts, and other factors that can affect these biological rhythms. This sensor technology can answer the need for the long-term and continuous monitoring of mobile mice, particularly those animals whose state of health is precarious as a result of genetic intervention and age that invasive monitoring means are not an option.

描述（由申请人提供）：第一阶段工作的结果，在此过程中确定了八只小鼠的生理信号并与已建立的“黄金标准”技术相关联，证明了监测和识别清晰可区分的生理信号的可行性通过使用鞍型传感器测量小鼠的胸部运动。更重要的是，结果清楚地表明，该传感器可以满足对移动小鼠进行长期持续监测的需求，特别是那些由于遗传干预和年龄而健康状况不稳定而侵入性监测手段无法实现的动物。一个选项。作为第二阶段工作的一部分，该系统将被小型化，以便整个传感组件可以移动到鼠标上，并且微型无线传输系统将集成到传感器系统中。实时信号处理算法将得到优化，并完成基于计算机的图形用户界面（GUI）。为了验证传感系统的性能，弗吉尼亚大学将针对健康状况脆弱且不允许进行侵入性监测的小鼠群体进行两项研究。一项研究将涉及患有诱导性强直性营养不良的小鼠，而另一项研究将研究哮喘小鼠。已与一家知名生理监测设备制造商结成联盟，将该产品商业化。随着用于测试药物反应、基因工程尝试和其他可能影响这些生物节律的因素的小鼠品系数量的增加，对小鼠心肺节律进行长期监测的需求也在增长。这种传感器技术可以满足对移动小鼠进行长期、连续监测的需求，特别是那些由于基因干预和年龄而健康状况不稳定的动物，而侵入性监测手段不可行。