Non-invasive cardiopulmonary monitor for mice

小鼠无创心肺监护仪

• 批准号: 6741565
• 负责人: MARTIN Carl BARUCH
• 金额: $ 9.95万
• 依托单位: EMPIRICAL TECHNOLOGIES CORPORATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-15 至 2004-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6741565
• 关键词: biomedical equipment development; biosensor device; blood pressure; cardiovascular function; computer system design /evaluation; electrocardiography; fiber optics; heart rate; laboratory mouse; monitoring device; noninvasive diagnosis; pulmonary respiration

DESCRIPTION (provided by applicant): The study of long-term variation in physiological cardiopulmonary rhythms in mice is rapidly expanding. The reason is that there are an ever-increasing number of strains of mice that have been genetically engineered to test scientific hypotheses about the molecular mechanisms of the cellular processes that control these biological rhythms. Since mice are so small, conventional recording systems need significant modification (indwelling vascular catheters) or are not applicable at all (skin electrodes). The development of a non-invasive sensor system for the continuous and reliable monitoring of respiratory rate, HR, and possibly blood pressure trends in mice is proposed. The sensor is based on a fiber-optic coupler sensor technology that has proven its applicability to physiological monitoring in humans in a number of applications. The sensor technology, which showed promising results in preliminary experiments, is very sensitive and scalable in size. The design of the sensor system, once it has been optimized using a "synthetic" mouse, will be tested on 8-10 mice that have been fitted with an EKG monitoring system commonly used in the mouse research community. The data will be analyzed and the reliability of the approach assessed using different algorithms, including wavelet transforms.

描述（由申请人提供）：小鼠生理心肺节奏的长期差异的研究正在迅速扩大。原因是，经过基因设计的小鼠菌株数量越来越多，用于检验有关控制这些生物节奏的细胞过程的分子机制的科学假设。由于小鼠是如此小，因此传统的记录系统需要重大修饰（留置血管导管）或根本不适用（皮肤电极）。 提出了无创的传感器系统的开发，用于对小鼠的呼吸率，HR和可能的血压趋势进行连续，可靠的监测。该传感器基于光纤耦合器传感器技术，该技术已证明其适用于许多应用中人类的生理监测。传感器技术在初步实验中显示出令人鼓舞的结果，其大小非常敏感且可扩展。 传感器系统的设计使用“合成”鼠标进行了优化后，将在8-10只小鼠上进行测试，这些小鼠已配备了鼠标研究社区中常用的EKG监测系统。 数据将进行分析，并使用不同算法（包括小波变换）评估该方法的可靠性。