JULIET

朱丽叶

• 批准号: 7603171
• 负责人: GARY R HUNTER
• 金额: $ 13.01万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603171
• 关键词: Activities of Daily Living; Aerobic; Behavior Therapy; Black race; Body Composition; Body Weight decreased; Cardiac; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Condition; Daily; Data; Diet; Effectiveness; Energy Metabolism; Epidemic; Exercise; Funding; Future; Grant; Institution; Insulin; Insulin Resistance; Isometric Exercise; Label; Life; Maintenance; Measures; Modeling; Morbidity - disease rate; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Physical Fitness; Physical activity; Physiological; Premenopause; Randomized; Research; Research Personnel; Resistance; Resources; Rest; Sampling; Source; Testing; Training; United States National Institutes of Health; Variant; Water; Week; Weight; Weight Gain; Weight maintenance regimen; Woman; energy balance; fitness; improved; insight; intravenous glucose tolerance test; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Identifying ways to increase physical activity (PA) is paramount to controlling the epidemic of obesity and its co-morbidities, including type 2 diabetes. For unknown reasons, post-obese women and black women appear to be especially prone to weight gain. Data from our current RO1 study suggest that inherent variations in resting energy expenditure and fuel utilization do not distinguish obesity-prone from obesity-resistant women or predict weight gain. By contrast, being of black race and having reduced strength, lower free-living PA, and lower total daily energy expenditure are strongly predictive of future weight gain. To extend our current studies in order to examine the effectiveness of exercise training to improve free-living PA and, in turn, energy balance and weight control. Specifically, we hypothesize that resistance exercise training will be more effective than aerobic and no exercise training in 1) increasing the physiologic ease of, and spontaneous engagement in physical activities of daily living, and 2) increasing total daily energy expenditure and weight-loss maintenance of obese black and white women. Obese premenopausal black and white women will be randomized to either diet-only, diet+aerobic or diet+resistance exercise training groups. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Testing will be done in the obese state, ~6 months later in the normal-weight post-obese state, and after 1 year of weight-loss maintenance. All testing will be under tightly controlled General Clinical Research Center conditions following 4 weeks of diet-controlled energy balance. Changes in body composition will be assessed by the 4-compartment model, and insulin resistance by the insulin modified, frequently-sampled intravenous glucose, tolerance test. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness (isometric tests); and spontaneous free-living PA, activity-related energy expenditure, non-exercise activity thermaogenesis, and total daily free-living energy expenditure (all derived from doubly labeled water). The results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance, especially in obesity-prone black women.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 确定增加体育活动的方法（PA）对于控制肥胖的流行及其合并症（包括2型糖尿病）至关重要。由于未知原因，后肥胖妇女和黑人妇女似乎特别容易体重增加。我们当前的RO1研究的数据表明，静息能量消耗和燃料利用方面的固有变化并不能区分肥胖症的妇女与耐肥胖女性或预测体重增加。相比之下，成为黑人种族，强度降低，自由生活的PA和降低的每日能量消耗降低，可以很好地预测未来的体重增加。 为了扩展我们目前的研究，以检查运动训练的有效性以改善自由生活的PA，进而能量平衡和体重控制。具体而言，我们假设抵抗运动训练将比有氧运动更有效，并且没有运动训练。1）提高生理易于性和自发的日常生活活动，以及2）增加日常的日常能量消耗和减肥量减肥。肥胖的黑白妇女。 肥胖的绝经前黑人和白人妇女将被随机分为饮食，饮食+有氧或饮食+抵抗运动训练组。在整个18个月的研究中，将提供有或没有有氧或抵抗运动训练的饮食/行为干预。测试将在肥胖状态下进行，〜6个月后，在正常的肥胖后状态，以及在减肥1年后进行测试。在饮食控制能量平衡4周后，所有测试将在严格控制的一般临床研究中心条件下。人体成分的变化将通过4室模型评估，并通过胰岛素修饰的，经常采样的静脉葡萄糖，耐受性测试来评估胰岛素抵抗。重大结果将包括运动的感知和生理困难的措施（心脏，通风，肌电图对标准化运动任务的反应）；有氧运动；力量适应性（等距测试）；以及自发的自由生活PA，与活动相关的能量消耗，非运动活性热发生和每日自由生活的能量消耗（全部源自双重标记的水）。 结果将为您提供有关不同类型的运动训练的有效性和机制的洞察力，可以改善身体健康，自发参与日常生活的体育活动，进而减轻体重减轻，尤其是在肥胖症的黑色中女性。