Effects of a higher protein diet and resistance training on fat free mass retention during weight loss in adults over 50: A Pilot Sequential Multiple Assignment Randomized Trial

高蛋白饮食和阻力训练对 50 岁以上成年人减肥期间无脂肪质量保留的影响：一项试点序贯多重分配随机试验

• 批准号: 10369646
• 负责人: Richard Drew Sayer
• 金额: $ 12.94万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-10 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10369646
• 关键词: Activities of Daily Living; Address; Adherence; Adult; Aerobic; Aging; Alabama; Automobile Driving; Award; Balance training; Behavior; Behavior Therapy; Body Composition; Body Weight decreased; Body fat; Clinical; Clinical Trials; Consumption; Counseling; Data; Development; Diet; Dietary Intervention; Dietary Proteins; Education; Effectiveness of Interventions; Enrollment; Ensure; Equilibrium; Exercise; Fatty acid glycerol esters; Funding; Goals; Grant; Health; Individual; Intervention; Intervention Trial; Knowledge; Lead; Maintenance; Mentored Research Scientist Development Award; Mentors; Metabolic; Metabolic Diseases; Monitor; Obesity; Outcomes Research; Participant; Phase; Pilot Projects; Proteins; Race; Randomized; Research; Research Project Grants; Resistance; Resources; Role; Scientist; Sequential Multiple Assignment Randomized Trial; Sex Differences; Supervision; Supplementation; Testing; Training; United States National Institutes of Health; Universities; Weight; Whey Protein; Woman; Yoga; aged; base; biological sex; career; career development; community setting; design; dietary restriction; disorder risk; effectiveness research; exercise intervention; exercise prescription; exercise training; feasibility trial; flexibility; functional loss; improved; intervention effect; men; muscle form; nutrition; preference; preservation; prevent; programs; recruit; rehabilitation research; response; sarcopenia; sarcopenic obesity; secondary analysis; skeletal muscle wasting; skills; strength training; treatment strategy; trial design; weight loss intervention; weight loss program

PROJECT SUMMARY/ABSTRACT Dr. Sayer’s career goal is to become an independent translational obesity scientist at the University of Alabama at Birmingham (UAB) with a research program focused on the development of pragmatic and adaptive weight loss interventions that can be rapidly implemented in clinical and community settings. The proposed K01 training plan and research project will provide the knowledge, skills, and abilities to launch his independent research career in pursuit of his long-term goals. Dr. Sayer’s training plan includes a combination of formal didactic training available through the UAB Center for Outcomes and Effectiveness Research and Education (directed by Dr. Kenneth Saag, Co-Mentor) as well as rigorous hands-on and personalized training through the NIH National Rehabilitation Research Resource to Enhance Clinical Trials (directed by Dr. Marcas Bamman, Co-Mentor), UAB Nutrition Obesity Research Center (directed by Dr. James Hill, Primary Mentor), and UAB Comprehensive Center for Health Aging (directed by Dr. Cynthia Brow, Co-Mentor). The proposed K01 research is a pilot Sequential Multiple Assignment Randomized Trial (SMART) using a high protein diet and resistance training to promote the retention of fat free mass during weight loss in men with obesity aged 50 and older. The primary objectives of the research are to provide critical preliminary data on 1) the feasibility of conducting a full-scale SMART, 2) estimates of intervention effects and their variances, and 3) moderators or predictors of intervention responsiveness that may serve as tailoring variables for a full-scale SMART. Dr. Sayer will leverage data and training resulting from the proposed K01 to successfully compete for R01-level research funding to develop and rigorously evaluate a full-scale SMART designed to construct an optimal adaptive treatment strategy using a HP diet and RT for preventing and/or treating sarcopenic obesity.

项目摘要/摘要 赛耶博士的职业目标是成为阿拉巴马大学的独立翻译肥胖科学家 在伯明翰（UAB）的研究计划侧重于发展务实和适应体重 可以在临床和社区环境中迅速实施的损失干预措施。拟议的K01培训 计划和研究项目将提供启动其独立研究的知识，技能和能力 追求他的长期目标的职业。 Sayer博士的培训计划包括正式的教学培训 可通过UAB成果和有效性研究和教育中心获得（由Dr.指导 肯尼斯·萨格（Kenneth Saag），联合学）以及通过NIH国民进行严格的实践和个性化培训 康复研究资源以增强临床试验（由联合学的Marcas Bamman博士指导），UAB 营养肥胖研究中心（由小学导师詹姆斯·希尔博士指导）和UAB综合 卫生衰老中心（由辛西娅·布劳（Cynthia Brow）博士指导）。拟议的K01研究是一名飞行员 顺序多次分配随机试验（SMART），使用高蛋白质饮食和抵抗训练 肥胖50岁及50岁的男性体重减轻期间促进无脂肪质量的保留。主要 该研究的目标是提供关键的初步数据1）进行全面进行的可行性 智能，2）估计干预效果及其差异，以及3）主持人或干预预测指标 响应能力可以作为全面智能的裁缝变量。 Sayer博士将利用数据， 拟议的K01导致的培训成功地争夺R01级研究资金，以发展和 严格评估了一个旨在使用HP构建最佳自适应治疗策略的全尺度智能 饮食和RT预防和/或治疗肌肉减少核对象。