JULIET

朱丽叶

• 批准号: 7380404
• 负责人: GARY R HUNTER
• 金额: $ 84.01万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380404
• 关键词: JULIET

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Identifying ways to increase physical activity (PA) is paramount to controlling the epidemic of obesity and its co-morbidities, including type 2 diabetes. For unknown reasons, post-obese women and black women appear to be especially prone to weight gain. To extend our current studies in order to examine the effectiveness of exercise training to improve free-living PA and, in turn, energy balance and weight control. Specifically, we hypothesize that resistance exercise training will be more effective than aerobic and no exercise training in 1) increasing the physiologic ease of, and spontaneous engagement in physical activities of daily living, and 2) increasing total daily energy expenditure and weight-loss maintenance of obese black and white women. Obese premenopausal black and white women will be randomized to either diet-only, diet+aerobic or diet+resistance exercise training groups. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Changes in body composition will be assessed by the 4-compartment model, and insulin resistance by the insulin modified, frequently-sampled intravenous glucose, tolerance test. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness (isometric tests); and spontaneous free-living PA, activity-related energy expenditure, non-exercise activity thermaogenesis, and total daily free-living energy expenditure (all derived from doubly labeled water).

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。确定增加体力活动 (PA) 的方法对于控制肥胖及其并发症（包括 2 型糖尿病）的流行至关重要。由于未知的原因，肥胖后女性和黑人女性似乎特别容易体重增加。 扩展我们目前的研究，以检验运动训练对改善自由生活 PA 的有效性，进而改善能量平衡和体重控制。具体来说，我们假设抗阻运动训练在以下方面比有氧运动和无运动训练更有效：1）增加日常生活身体活动的生理舒适度和自发参与度，2）增加每日总能量消耗和减肥维持肥胖的黑人和白人妇女。 肥胖的绝经前黑人和白人女性将被随机分为纯饮食组、饮食+有氧运动组或饮食+阻力运动训练组。在整个 18 个月的研究中，将提供饮食/行为干预，无论是否进行有氧或阻力运动训练。身体成分的变化将通过四室模型进行评估，胰岛素抵抗则通过胰岛素改良、频繁采样的静脉葡萄糖耐受试验进行评估。主要结果将包括对运动的感知和生理难度的测量（对标准化运动任务的心脏、通气、肌电反应）；有氧健身；力量健身（等长测试）；自发性自由生活能量消耗、与活动相关的能量消耗、非运动活动生热作用以及每日自由生活能量消耗总量（全部来自双标记水）。