COGNITION IN CHILDREN WITH SICKLE CELL ANEMIA

镰状细胞性贫血儿童的认知

• 批准号: 7603409
• 负责人: Allison A King
• 金额: $ 0.41万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603409
• 关键词: Anemia; Blood Transfusion; Cerebrum; Child; Clinical; Cognition; Cognitive; Cognitive deficits; Computer Retrieval of Information on Scientific Projects Database; Emotional; Enrollment; Epidemiologic Studies; Funding; Goals; Grant; Impaired cognition; Infarction; Institution; Intervention; Magnetic Resonance Imaging; Measures; Mental Depression; Morbidity - disease rate; Mothers; Neurologic; Participant; Patient Self-Report; Poverty; Research; Research Personnel; Resources; Risk Factors; Sickle Cell Anemia; Source; Testing; United States National Institutes of Health; Vulnerable Populations; base; cognitive function; cohort; coping; instrument; maternal depression; parent project; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this proposal is to determine what factors other than cerebral infarcts and anemia contribute to cognitive deficits in children with sickle cell anemia (SCA). Research has shown that at least 30% of SCA children without cerebral infarcts have significant cognitive deficits. We propose two interrelated projects in prospective cohorts of children with SCA to explore the relationships of poverty, maternal depression and maternal coping mechanisms with cognitive function. We plan to enroll 100 children from the Silent Cerebral Infarct Trial (SIT; a multi-center trial to determine whether blood transfusion therapy decreases neurologic morbidity in SCA children with silent cerebral infarcts) and 80 children who have no infarct on MRI. All children will complete cognitive testing twice over three years. In the first project, parents will self-report annual SES measures, and we will document academic status and clinical information of the participants. In the second project, mothers will also be asked to complete the Center for Epidemiologic Studies Depression Scale (CES-D) instrument to determine any influence of maternal emotional status on the children's cognition. We will test two hypotheses in children with SCA and no cerebral infarct: Primary Hypothesis: SES is an independent risk factor for significant cognitive deficits. Secondary Hypothesis: Maternal depression is associated with child cognitive impairments. After completion of this study, we hope to be able to determine risk factors for poor cognition in children with SCA without cerebral infarcts and provide the basis for potential interventions to increase cognition in this vulnerable population.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该提案的目标是确定除了脑梗塞和贫血之外，哪些因素会导致镰状细胞性贫血（SCA）儿童的认知缺陷。 研究表明，至少30%的没有脑梗塞的SCA儿童存在明显的认知缺陷。 我们在 SCA 儿童的前瞻性队列中提出了两个相互关联的项目，以探讨贫困、母亲抑郁和母亲应对机制与认知功能的关系。 我们计划招募 100 名无症状脑梗塞试验（SIT；一项多中心试验，旨在确定输血疗法是否能降低患有无症状脑梗塞的 SCA 儿童的神经系统发病率）的 100 名儿童和 80 名 MRI 上未发现梗塞的儿童。 所有儿童将在三年内完成两次认知测试。 在第一个项目中，家长将自我报告年度 SES 指标，我们将记录参与者的学术状况和临床信息。 在第二个项目中，母亲们还将被要求填写流行病学研究中心抑郁量表（CES-D）工具，以确定母亲情绪状态对孩子认知的影响。 我们将在患有 SCA 但没有脑梗塞的儿童中检验两个假设： 主要假设：SES 是显着认知缺陷的独立危险因素。 第二个假设：母亲抑郁与儿童认知障碍有关。 这项研究完成后，我们希望能够确定无脑梗塞的 SCA 儿童认知不良的危险因素，并为提高这一弱势群体认知能力的潜在干预措施提供基础。