AEROBIC EXERCISE AND PLASMA TRIGLYCERIDE CONCENTRATION

有氧运动和血浆甘油三酯浓度

• 批准号: 7603359
• 负责人: Bettina Mittendorfer
• 金额: $ 0.88万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603359
• 关键词: Aerobic Exercise; Cardiovascular Diseases; Computer Retrieval of Information on Scientific Projects Database; Conflict (Psychology); Consumption; Data; Exercise; Fatty acid glycerol esters; Funding; Grant; Guidelines; Hepatic; Hour; Hyperinsulinism; Ingestion; Institution; Measures; Metabolic; Metabolic Control; Metabolism; Physical activity; Plasma; Research; Research Personnel; Resources; Rest; Risk Factors; Source; Stable Isotope Labeling; Techniques; Testing; Tracer; Triglycerides; United States National Institutes of Health; improved; very low density lipoprotein triglyceride

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Elevated postabsorptive and postprandial plasma triglyceride (TG) concentrations are associated with increased cardiovascular disease (CVD). This suggest that total plasma TG load (24-hour plasma TG concentration) is an important risk factor for CVD. Although exercise is associated with decreased CVD, its effect on plasma TG concentration and metabolism is not clear. 1) Data from studies investigating the effects of exercise on postabsorptive plasma TG concentration are conflicting. 2) There is good evidence that exercise lowers the rise in plasma TG concentration after consumption of a single high-fat test meal. However, the effects of exercise on postprandial plasma TG concentration after ingestion of a typical mixed meal are largely unknown, and the effects of exercise on 24-hour plasma TG concentration has never been studied. 3) The mechanisms responsible for the postprandial TG-lowering effect of exercise remain unclear. The primary objectives of this proposal are to evaluate the effects of exercise on 24-hour plasma TG concentration, and to determine potential metabolic mechanisms responsible for the exercise-induced changes in plasma TG concentration. We hypothesize that: 1) Exercise decreases total 24-hour plasma TG concentration, predominately by lowering plasma TG concentration after meals, 2) Exercise in the morning has a greater effect on total 24-hour plasma TG concentration than exercise performed in the evening, and 3) The exercise-induced decrease in postprandial plasma TG concentration is, at least in part, due to lower hepatic VLDL-TG secretion during postprandial hyperinsulinemia. To test our hypothesis we will measure plasma TG concentration every hour for 24 hours and measure hepatic VLDL-TG secretion (by using stable isotope labeled tracer techniques) during hyperinsulinemia in subjects with increased plasma TG concentrations after rest and exercise. The data generated from concenration the proposed studies will improve our understanding of the metabolic control of plasma TG concentration. Furthermore, they will help establish appropriate guidelines to lower plasma TG concentration via physical activity.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 升高后血浆甘油三酸酯（TG）浓度升高与心血管疾病增加（CVD）有关。 这表明总血浆TG负载（24小时等离子体TG浓度）是CVD的重要危险因素。 尽管运动与CVD降低有关，但其对等离子体TG浓度和代谢的影响尚不清楚。 1）研究研究锻炼对吸收后血浆TG浓度的影响的数据矛盾。 2）有充分的证据表明，在消耗单一高脂测试餐后，运动降低了血浆TG浓度的升高。 然而，摄入典型的混合餐后运动对餐后血浆TG浓度的影响是未知的，并且从未研究过运动对24小时血浆TG浓度的影响。 3）尚不清楚导致餐后降低TG的机制。 该提案的主要目标是评估运动对24小时血浆TG浓度的影响，并确定导致运动引起的血浆TG浓度变化的潜在代谢机制。 我们假设这一点： 1）运动降低总24小时血浆TG浓度，主要通过降低餐后血浆TG浓度， 2）早上运动对24小时血浆TG浓度的影响比晚上进行的运动更大，并且 3）运动引起的餐后血浆TG浓度的降低至少部分是由于餐后高胰岛素血症期间肝VLDL-TG分泌较低。 为了检验我们的假设，我们将在高胰岛素血症期间每小时测量每小时24小时的血浆TG浓度，并测量肝VLDL-TG分泌（通过使用稳定的同位素标记的示踪剂技术使用稳定的同位素标记的示踪剂技术），在静止和运动后血浆TG浓度升高的受试者中。 通过浓度产生的数据拟议的研究将提高我们对血浆TG浓度的代谢控制的理解。 此外，它们将有助于建立适当的指南，以通过体育锻炼降低血浆TG浓度。