AGE, LIFESTYLE, MUSCLE MECHANISMS IN INSULIN RESISTANCE

年龄、生活方式、肌肉胰岛素抵抗机制

• 批准号: 7608153
• 负责人: LYNDON J O JOSEPH
• 金额: $ 0.14万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608153
• 关键词: Aerobic Exercise; Affect; Age; Aging; Body Weight decreased; Body mass index; Cardiovascular system; Computer Retrieval of Information on Scientific Projects Database; Euglycemic Clamping; Funding; Glucose; Glucose Clamp; Grant; Heart Rate; Hyperlipidemia; Hypertension; Individual; Institution; Insulin Resistance; Life Style; Metabolic; Metabolic Diseases; Molecular; Morbidity - disease rate; Muscle; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Phosphorylation; Rate; Research; Research Personnel; Resources; Skeletal Muscle; Source; United States National Institutes of Health; Woman; day; design; glucose tolerance; improved; insulin sensitivity; insulin signaling; lifestyle intervention; men; mortality; Aerobic Exercise; Affect; Age; Aging; Body Weight decreased; Body mass index; Cardiovascular system; Computer Retrieval of Information on Scientific Projects Database; Euglycemic Clamping; Funding; Glucose; Glucose Clamp; Grant; Heart Rate; Hyperlipidemia; Hypertension; Individual; Institution; Insulin Resistance; Life Style; Metabolic; Metabolic Diseases; Molecular; Morbidity - disease rate; Muscle; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Phosphorylation; Rate; Research; Research Personnel; Resources; Skeletal Muscle; Source; United States National Institutes of Health; Woman; day; design; glucose tolerance; improved; insulin sensitivity; insulin signaling; lifestyle intervention; men; mortality

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Aging is associated with an increase in insulin resistance that may be affected more by obesity and physical inactivity than age per se. Insulin resistance is an underlying abnormality in various metabolic disorders such as type 2 diabetes, hyperlipidemia, and hypertension; metabolic diseases that increase cardiovascular morbidity and mortality with aging. Numerous studies show that moderate weight loss (WL) plus aerobic exercise (AEX) improve glucose tolerance and insulin sensitivity in older individuals. However, the molecular and cellular mechanisms underlying these metabolic changes with WL+AEX are not certain. Hypothesis/Design: It is our hypothesis that a lifestyle intervention that incorporates a moderate rate of WL (250-350 kcal/day deficit) plus AEX (70-75% heart rate reserve) will improve glucose tolerance and glucose utilization (80 mU/m2/min hyperinsulinemic-euglycemic clamp) in overweight (25-35 kg/m2 body mass index), older (60-75 y) glucose intolerant men and women through cellular mechanisms that involve increases in the content, phosphorylation, or activity of intermediates of the insulin-signaling cascade in skeletal muscle.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：衰老与肥胖和身体不活跃更大的胰岛素耐药性的增加相比，与年龄相比，衰老可能更大。 胰岛素抵抗是各种代谢性疾病（例如2型糖尿病，高脂血症和高血压）的潜在异常。随着衰老而增加心血管发病率和死亡率的代谢疾病。 大量研究表明，中等体重减轻（WL）加氧运动（AEX）提高了老年人的葡萄糖耐量和胰岛素敏感性。 但是，这些代谢变化与WL+AEX的分子和细胞机制尚不确定。 Hypothesis/Design: It is our hypothesis that a lifestyle intervention that incorporates a moderate rate of WL (250-350 kcal/day deficit) plus AEX (70-75% heart rate reserve) will improve glucose tolerance and glucose utilization (80 mU/m2/min hyperinsulinemic-euglycemic clamp) in overweight (25-35 kg/m2 body mass index), older （60-75 y）葡萄糖不耐受的男性和女性通过涉及骨骼肌中胰岛素信号级联反应的含量，磷酸化或活性增加的细胞机制。