EFFECT OF ENDURANCE EXERCISE ON VLDL-TG METABOLISM

耐力运动对 VLDL-TG 代谢的影响

• 批准号: 7377197
• 负责人: Bettina Mittendorfer
• 金额: $ 3.29万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377197
• 关键词: EFFECT; ENDURANCE; EXERCISE; VLDL; TG

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Endurance exercise is important fo a healthy life: it is essential for long term weight management and is involved in the prevention of cardiovascular disease (CVD), presumably via its ability to lower plasma triglyceride (TG) concentrations (both under fasted conditions and after a meal). There is a direct relationship between elevated plasma TG contrations, 1,2, which are commonly observed in obese persons3, and CVD, particularly in women 4,5. According to a recent report by the American Heart Association, >40% of female deaths in the US and most developed countries occur from CVD, one-third is thought to be attributable to inactivity6. The mechanisms that are responsible for the exercise-induced reduction in plasma TG concentrations are not known. In order to optimize therapies for the prevention of CVD, however, it is ultimately necessary to understand the factors that control plasma TG concentrations. Furthermore, most studies that sougth to investigate potential mechanism(s) for the decrease in plasma TG concentration in response to exercise to date have been performed in lean, oftentimes trained, men but not in obese persons and women. We 7-9, and others 10-11, found that both sex and adiposity affect lipik metabolism, which preludes the generalization of findings from lean subjects and men and underlines the importance of studies specifically targeted to women and obese subjects.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。耐力运动是健康的重要生活：它对于长期体重管理至关重要，并且参与预防心血管疾病（CVD），这可能是通过降低血浆甘油三酸酯（TG）浓度（包括在禁食条件下和进餐后）的能力。血浆TG对照升高之间存在直接关系，1,2通常在肥胖者3和CVD中观察到，尤其是在女性4,5中。根据美国心脏协会最近的一份报告，美国和大多数发达国家的女性死亡中有40％来自CVD，认为三分之一被认为归因于无活动6。尚不清楚导致运动引起的血浆TG浓度降低的机制。但是，为了优化预防CVD的疗法，最终有必要了解控制血浆TG浓度的因素。此外，大多数研究都在研究迄今为止响应于运动的血浆TG浓度降低的潜在机制的大多数研究是在瘦弱的，经常受过训练的男性中进行的，但在肥胖的人和女性中没有进行。我们7-9和其他人10-11发现，性和肥胖都会影响Lipik代谢，这预定了来自精益受试者和男人的发现的概括，并强调了针对女性和肥胖受试者的研究的重要性。