MENOPAUSAL SYMPTOMS AND METABOLIC SYNDROME: A FEASIBILITY STUDY

更年期症状和代谢综合征：可行性研究

• 批准号: 7603487
• 负责人: CAROL A LANDIS
• 金额: $ 0.05万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603487
• 关键词: Adult; Arousal; Awareness; Cardiovascular Diseases; Cessation of life; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Discipline of Nursing; Elderly; Estrogens; Feasibility Studies; Funding; Grant; Hormones; Hostility; Hot flushes; Hydrocortisone; Incidence; Inflammatory; Institution; Insulin Resistance; Intervention; Link; Longitudinal Studies; Menopausal Symptom; Menopausal hot flushes; Menopause; Metabolic syndrome; Night Sweating; Perimenopause; Physiological; Postmenopause; Process; Protocols documentation; Psychosocial Factor; Purpose; Research; Research Personnel; Resources; Risk; Science; Sleep; Sleep disturbances; Source; Stress; Study Section; Symptoms; Therapeutic; United States National Institutes of Health; Woman; Women' s Health; cardiovascular disorder risk; day; design; disability; improved; indexing; older women

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Menopause-related symptoms, especially hot flashes and night sweats, are poorly understood and few effective therapeutics exist since the Women's Health Initiative (WHI) findings heightened awareness of the risks of using hormones/estrogen to treat them. Sleep disturbance has been linked to nocturnal hot flashes and to indices of physiological arousal (e.g., elevated cortisol, insulin resistance, heightened autonomic tone, and inflammatory processes) that could contribute to development of metabolic syndrome signs that emerge during the menopause transition and is associated with elevated cardiovascular disease (CVD) risk after menopause. CVD is the leading cause of significant disability and death in older women. Interventions to reduce menopausal symptoms and improve sleep are needed but in order to design them, it is necessary to understand the relations among hot flashes, sleep disturbance, physiological reactivity, and the way psychosocial factors moderate these relations (e.g., hostility/anger). We are re-submitting a longitudinal study to describe relations among hot flashes, sleep disturbance, and indicators of metabolic syndrome, and how stress reactivity and psychosocial factors moderate these relations in late perimenopause and the first few years postmenopause when the incidence of hot flashes and sleep disturbance is highest (1 R01 NR009365-01). Reviewers from the Nursing Science Adult and Older Adult study section requested feasibility data of protocol completion. Thus, the purpose of this study is to document the feasibility of implementing our 17-day study protocol in 5 women for our resubmission.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 更年期相关的症状，尤其是炎热的闪光和汗汗，人们对妇女健康计划（WHI）的发现提高了人们对使用激素/雌激素治疗它们的风险的认识，因此很少有有效的治疗方法。睡眠障碍与夜间潮热和生理唤醒的指标有关（例如，皮质醇升高，胰岛素抵抗，自主性升高和炎症过程）可能有助于代谢综合征的发展，这些综合征在过渡期间出现，并且在过渡过程中与心脏疾病升高相关联（COVD）。 CVD是老年妇女严重残疾和死亡的主要原因。需要采取干预措施来减轻绝经症状和改善睡眠，但是为了设计它们，有必要了解炎热的闪光，睡眠障碍，生理反应性以及心理社会因素适应这些关系的方式（例如敌意/愤怒）。我们正在重新提交一项纵向研究，以描述潮热，睡眠障碍和代谢综合征指标之间的关系，以及压力反应性反应性和心理社会因素如何在上周末和绝经后的头几年中调节这些关系，当时热闪光和睡眠障碍的发生率最高（1 R01 NR001 NR0093655-01）。护理科学成人和老年人研究部分的审阅者要求完成协议完成的可行性数据。因此，这项研究的目的是记录在5名妇女重新接受我们的17天学习方案的可行性。