CAMP Continuation Study/Phse 2 (CAMPCS/2)

CAMP 继续研究/第 2 阶段 (CAMPCS/2)

• 批准号: 7095110
• 负责人: HAROLD WILLIAM KELLY
• 金额: $ 20.51万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2007-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7095110
• 关键词: adolescence (12-20); asthma; body height; child physical development; clinical research; cooperative study; corticosteroids; drug adverse effect; human subject; longitudinal human study; lung development; patient care management; respiratory disorder epidemiology; young adult human (21-34)

The primary hypothesis to be tested is whether 3.5-5 years treatment of asthma in children 5-12 years of age with inhaled corticosteroids has a long-term benefit in allowing maximum attainment of lung growth. This will be achieved by continued followup of the original Childhood Asthma Management Program (CAMP) cohort until the majority have reached their maximal adult height. The Albuquerque site agrees to continue to follow and obtain the necessary measurements in their cohort to fulfill all of the specific aims as described in the Washington University, St. Louis scientific protocol. One hundred twenty-one patients were initially randomized at the Albuquerque site and we currently have 100 patients enrolled in the CAMPCS cohort followup study. Of those patients currently enrolled in CAMPCS we have successfully completed 96% of all pulmonary function measures, 97% of all linear growth measures and 93% of all methacholine challenge measures up to August 2002. All of the original cohort which consisted of 41% minorities and 40% females is eligible to participate and we will attempt to contact them all, even those not currently enrolled in CAMPCS.

待检验的主要假设是，用吸入皮质类固醇治疗 5-12 岁儿童哮喘 3.5-5 年是否具有长期益处，可最大程度地实现肺部生长。这将通过对最初的儿童哮喘管理计划 (CAMP) 队列的持续随访来实现，直到大多数人达到成年最大身高。阿尔伯克基站点同意继续跟踪并获得其队列中必要的测量结果，以实现圣路易斯华盛顿大学科学协议中描述的所有具体目标。最初在阿尔伯克基中心随机分配了 121 名患者，目前我们有 100 名患者加入了 CAMPCS 队列 后续研究。截至 2002 年 8 月，在目前参加 CAMPCS 的患者中，我们已成功完成了 96% 的所有肺功能测量、97% 的所有线性生长测量和 93% 的所有乙酰甲胆碱激发测量。所有原始队列均由 41% 的少数族裔组成40% 的女性有资格参加，我们将尝试联系所有人，即使是目前未注册 CAMPCS 的女性。