CAMP Continuation Study / Phase 2 (CAMPCS2)

CAMP 继续研究/第 2 阶段 (CAMPCS2)

• 批准号: 7096606
• 负责人: HARTMUT GRASEMANN
• 金额: $ 18.23万
• 依托单位: HOSPITAL FOR SICK CHLDRN (TORONTO)
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2007-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7096606
• 关键词: adolescence (12-20); asthma; body height; child physical development; clinical research; cooperative study; corticosteroids; drug adverse effect; human subject; longitudinal human study; lung development; respiratory disorder epidemiology; young adult human (21-34)

This application is for the Toronto Hospital for Sick Children to participate in the Childhood Asthma Management Program Continuation Study/Phase 2 (CAMPCS/2). The abstract and research plan for CAMPCS/2 is included in the application from the Washington University (Robert Strunk, PI). The specific aims of the projected study are the continued follow up and evaluation of this patient population through to adulthood, in order to better describe the impact of a. mild to moderate asthma on lung growth and airway remodelling asthma, and b. inhaled corticosteroids on eventual adult height. This is a long term observational study. The study population are children with mild to moderate asthma, originally enrolled in a placebo controlled trial of asthma therapy (the CAMP study). The Toronto CAMP Centre has been a participant in this multi-centred study since its inception in 1993 as the Childhood Asthma Management Program (CAMP). The Toronto CAMP clinic is committed to participate in CAMP/CS2 and supports the continued follow up of CAMP patients. We initially enrolled 125 patients in CAMP, and subsequently enrolled 109 patients in CAMPCS, with one subsequently re-enrolling. The families and patients participating in CAMPCS continue to be committed to the study and have expressed an interest in maintaining this relationship. We therefore anticipate their continued involvement through CAMPCS/2, and optimistic for 100% continued enrollment. There have been no changes in CAMPCS personnel (PI and nurse coordinators unchanged in 5 years), and they too remain committed to continuing this valuable study. We will therefore continue to collect data of high quality.

此申请是为了多伦多病童医院参与儿童哮喘项目 管理计划继续研究/第二阶段 (CAMPCS/2)。 CAMPCS/2 的摘要和研究计划包含在华盛顿大学（Robert Strunk，PI）的申请中。预计研究的具体目标是持续跟踪和评估该患者群体直至成年，以便更好地描述 a 的影响。轻度至中度哮喘对肺生长和气道重塑的影响；b．根据最终成年身高吸入皮质类固醇。这是一项长期观察性研究。研究人群是患有轻度至中度哮喘的儿童，最初参加了哮喘治疗的安慰剂对照试验（CAMP 研究）。多伦多 CAMP 中心自 1993 年作为儿童哮喘管理计划 (CAMP) 启动以来一直参与这项多中心研究。多伦多CAMP诊所致力于参与CAMP/CS2并支持CAMP患者的持续随访。我们最初在 CAMP 中招募了 125 名患者，随后在 CAMPCS 中招募了 109 名患者，随后又重新招募了 1 名患者。参与 CAMPCS 的家庭和患者继续致力于这项研究，并表示有兴趣维持这种关系。因此，我们预计他们将通过 CAMPCS/2 继续参与，并对 100% 的持续注册率持乐观态度。 CAMPCS 人员没有变化（PI 护士协调员在 5 年内没有变化），他们也仍然致力于继续这项有价值的研究。因此，我们将继续收集高质量的数据。