Cortical/Subcortical Circuits in Late-Life Depression

晚年抑郁症的皮质/皮质下回路

• 批准号: 7148998
• 负责人: ANAND KUMAR
• 金额: $ 58.27万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-08 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7148998
• 关键词: aspartate; behavioral /social science research tag; bioimaging /biomedical imaging; brain interhemispheric activity; brain mapping; brain metabolism; cerebral cortex; choline; clinical research; cognition; cognition disorders; executive function; human old age (65+); human subject; inositol; magnetic resonance imaging; major depression; neurochemistry; neuroimaging; neuropsychological tests; nuclear magnetic resonance spectroscopy; psychological aspect of aging; psychopathology; short term memory

DESCRIPTION (provided by applicant): The objective of the proposed study is to examine the biological status of cortical-subcortical circuits in the pathophysiology of late-life major depressive disorder (MDD) by integrating magnetic resonance imaging (MRI) derived measures of brain biochemistry with relevant measures of cognition. We propose to use magnetic resonance spectroscopy (MRS) on a 3 Tesla scanner to estimate absolute and normalized levels of N-Acetyl Aspartate, Choline and Myoinositol in the dorsolateral white matter and subcortical nuclei bilaterally in patients with MDD and controls. Magnetization transfer (MT) is a complementary technique that will be used to examine the status of myelin and related macromolecular proteins in the frontal white matter and subcortical regions. Measures of executive function, working memory, verbal and non-verbal learning and recall -- domains that reflect dorsolateral frontal lobe and subcortical functioning will also be obtained from our patient and control groups. Integrating biochemical measures with relevant cognitive indices will help us to critically examine the status of cortical-subcortical circuits in the pathophysiology of MDD. While the clinical impact of late-life MDD is widely acknowledged, its biological basis remains poorly characterized. The role of the frontal white matter and subcortical nuclei in the etiology of late-life MDD has received scant attention and the proposed studies will help us elucidate the mechanisms and pathways that lead to MDD in late-life.

描述（由申请人提供）：拟议研究的目的是通过整合磁共振成像（MRI）衍生的大脑生物化学测量来检查晚年重度抑郁症（MDD）病理生理学中皮质-皮质下回路的生物学状态以及相关的认知测量。我们建议在 3 特斯拉扫描仪上使用磁共振波谱 (MRS) 来估计 MDD 患者和对照患者背外侧白质和双侧皮质下核中 N-乙酰天冬氨酸、胆碱和肌醇的绝对和标准化水平。磁化转移 (MT) 是一种补充技术，将用于检查额叶白质和皮质下区域中髓磷脂和相关大分子蛋白的状态。执行功能、工作记忆、语言和非语言学习和回忆的测量——反映背外侧额叶和皮质下功能的领域也将从我们的患者和对照组中获得。将生化指标与相关认知指标相结合将有助于我们批判性地研究MDD病理生理学中皮质-皮质下回路的状态。虽然晚年 MDD 的临床影响已得到广泛认可，但其生物学基础仍知之甚少。额叶白质和皮质下核团在晚年 MDD 病因学中的作用很少受到关注，拟议的研究将帮助我们阐明导致晚年 MDD 的机制和途径。