A Program of Research and Mentorship on Alcoholism and Co-occuring Disorders

关于酗酒和并发疾病的研究和指导计划

• 批准号: 7313637
• 负责人: Michael Parks Bogenschutz
• 金额: $ 16.41万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-20 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7313637
• 关键词: Alcohol dependence; Alcoholism; Anxiety Disorders; Benzodiazepines; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Comorbidity; Condition; Development; Diagnosis; Disease; Disulfiram; Doctor of Philosophy; Educational Activities; Faculty; Funding; Goals; Grant; Image; Individual; Learning; Medical Students; Mental disorders; Mentally Ill Persons; Mentors; Mentorship; Methodology; Mid-Career Clinical Scientist Award (K24); Mind; Modeling; National Institute of Drug Abuse; New Mexico; Patients; Persons; Population; Psychiatry; Publishing; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Students; Substance abuse problem; Training and Education; United States National Institutes of Health; Universities; Week; addiction; alcohol use disorder; base; cost; experience; medical schools; member; next generation; novel; novel strategies; problem drinker; programs

DESCRIPTION (provided by applicant): I want to achieve two goals in the next 5 years through this K24 award: to deepen my own program of research, focusing on the treatment of dually diagnosed persons, and to facilitate the development of a more extensive program of clinical research in addictions at the University of New Mexico by helping to develop the next generation of clinical researchers at our facilities. My research to date has focused on clinical trials, mutual help approaches for the dually diagnosed, and other research on comorbidity and 12-step programs. Current grant funding includes an R01 grant to study the efficacy of a modified 12-step facilitation therapy for seriously mentally ill alcoholics (R01AA015419), and a U10 grant for the Southwest Node of the NIDA Clinical Trials Network (U10DA1533). I have extensive research mentoring experience with junior faculty, fellows, psychiatric residents, Ph.D. candidates, and medical students. Institutional resources for research and mentorship in addictions include faculty, trainees, and infrastructure at the UNM Center on Alcoholism, Substance Abuse, and Addiction, the School of Medicine, and the MIND Imaging Center, as well as diverse and accessible clinical populations. Six Specific Aims are proposed. The research Specific Aims are 1) To leam methodologies critical to the development of programmatic clinical research on comorbid conditions; 2) To conduct preliminary studies supporting the development of a novel pharrnacotherapeutic approach for individuals with alcohol dependence and co-occurring anxiety disorders, involving the co-administration of disulfiram and a benzodiazepine a 16-week model of treatment; 3) To develop, submit, and obtain funding for an R01 grant studying this pharrnacotherapeutic approach. The mentorship Specific Aims are 4) to mentor at least 3 junior faculty members to the point of submitting proposals for independent NIH funding; 5) to provide research training to at least three addiction psychiatry fellows, graduate students, or psychiatry residents per year through participation in ongoing research projects; and 6) To provide ongoing training and education to a broader group through a variety of lower-intensity mentorship and educational activities. Relevance: Mental illness and alcoholism frequently occur together, resulting in disproportionate suffering and cost. There is a need for better understanding and more effective treatments for these conditions. This grant supports the development of new research approaches and new researchers in this important field.

描述（由申请人提供）：我希望通过这个 K24 奖项在未来 5 年内实现两个目标：深化我自己的研究计划，重点关注双重诊断患者的治疗，并促进更广泛计划的开发通过帮助在我们的设施中培养下一代临床研究人员，在新墨西哥大学开展成瘾临床研究。迄今为止，我的研究重点是临床试验、双重诊断的互助方法，以及其他关于合并症和 12 步计划的研究。目前的拨款包括 R01 拨款，用于研究改良的 12 步促进疗法的功效 严重精神疾病酗酒者 (R01AA015419)，以及 NIDA 西南节点的 U10 赠款 临床试验网络（U10DA1533）。我对初级教师、研究员、精神病住院医师、博士生有丰富的研究指导经验。候选人和医学生。成瘾研究和指导的机构资源包括新墨西哥大学酗酒、药物滥用和成瘾中心、医学院和 MIND 成像中心的教职人员、实习生和基础设施，以及多样化且易于接触的临床人群。提出了六项具体目标。 该研究的具体目标是 1) 学习对于共病病症的程序性临床研究发展至关重要的方法； 2) 进行初步研究，支持为酒精依赖和同时发生的焦虑症患者开发一种新的药物治疗方法，包括双硫仑和苯二氮卓类药物联合给药，为期 16 周的治疗模型； 3) 制定、提交研究这种药物治疗方法的 R01 拨款并获得资金。指导的具体目标是 4) 指导至少 3 名初级教员，以提交独立 NIH 资助的提案； 5) 通过参与正在进行的研究项目，每年向至少三名成瘾精神病学研究员、研究生或精神病学住院医师提供研究培训； 6) 通过各种低强度的指导和教育活动，向更广泛的群体提供持续的培训和教育。 相关性：精神疾病和酗酒经常同时发生，导致不成比例的痛苦和成本。需要更好地了解这些病症并采取更有效的治疗方法。这笔赠款支持这一重要领域新研究方法和新研究人员的发展。