Epidemiology Of Complications Of Type 2 Diabetes Mellitu

2 型糖尿病并发症的流行病学

• 批准号: 7337545
• 负责人: WILLIAM C KNOWLER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7337545
• 关键词: Epidemiology; Complications; Type; Diabetes; Mellitu

The purpose of this project is to determine the incidence rates, rates of progression, and risk factors for the chronic complications of type 2 diabetes. The study is conducted in the Pima Indians of the Gila River Indian Community, who have participated in a longitudinal epidemiologic study since 1965 (see project Z01 DK 69000). Risk factors for the major complications of diabetes, retinopathy, nephropathy, and coronary artery disease, are determined by longitudinal follow-up of diabetic subjects. Methods of ascertainment of these complications include fundus photography, measurement of urine albumin and serum creatinine concentrations, and electrocardiography. The incidence of diabetic nephropathy, as a function of duration of diabetes, was similar in those with diabetes onset in youth compared with older onset diabetes, and the rate of retinopathy was only slightly lower in youth. Thus, by the time they reach middle adult years, Pima Indians with youth-onset diabetes have rates of advanced diabetes complications similar to those of older adults who have had diabetes for the same length of time. Periodontal disease, a common infectious complication of diabetes, more than doubled the incidence rate of fatal heart disease in Pima Indian adults with diabetes. We continue to search for genetic determinants of diabetic complications, including a genome-wide linkage study of diabetic retinopathy and a multicentered genetic linkage study (Family Investigation of Nephropathy and Diabetes) of diabetic nephropathy in an attempt to identify susceptibility genes for nephropathy. Several positional candidate genes are being evaluated.

该项目的目的是确定2型糖尿病的慢性并发症的发病率，进展率和危险因素。这项研究是在吉拉河印度社区的皮马印第安人进行的，他们自1965年以来就参加了一项纵向流行病学研究（请参阅Z01 DK 69000项目）。糖尿病，视网膜病，肾病和冠状动脉疾病的主要并发症的危险因素由糖尿病患者的纵向随访确定。确定这些并发症的方法包括眼底摄影，尿白蛋白和血清肌酐浓度的测量以及心电图。与年龄较大的糖尿病相比，在糖尿病发作的患者中，糖尿病性肾病的发生率与糖尿病的持续时间相似，视网膜病的发生率仅在青年中略低。因此，到成年成年年级的时候，患有青年糖尿病的皮马印第安人的晚期糖尿病并发症发生率类似于患有糖尿病的老年人的并发症。牙周疾病是一种常见的糖尿病感染并发症，使皮马印度糖尿病成年人的致命心脏病发病率翻了一番。我们继续寻找糖尿病并发症的遗传决定因素，包括糖尿病性视网膜病的全基因组连接研究以及糖尿病性肾病的多中心遗传联系研究（家庭研究（家庭研究肾病和糖尿病的家庭研究）），以试图鉴定肾病的易感基因。正在评估几个位置候选基因。