EPIDEMIOLOGY OF COMPLICATIONS OF NON-INSULIN DEPENDENT DIABETES

非胰岛素依赖型糖尿病并发症的流行病学

• 批准号: 6432204
• 负责人: WILLIAM C KNOWLER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6432204
• 关键词: Native Americans; albuminuria; biomarker; blood chemistry; child (0-11); clinical research; coronary artery; diabetes mellitus genetics; diabetic angiopathy; diabetic nephropathy; diabetic neuropathy; diabetic retinopathy; electrocardiography; epidemiology; eye fundus photography; family genetics; gene environment interaction; human subject; hypertension; longitudinal human study; medical complication; noninsulin dependent diabetes mellitus; pathologic process; urinalysis

The purpose of this project is to determine the incidence rates, rates of progression, and risk factors for the chronic complications of type 2 diabetes. The study is conducted in the Pima Indians of the Gila River Indian Community, who have participated in a longitudinal epidemiologic study since 1965 (see project Z01 DK 69000). Risk factors for the major complications of diabetes, retinopathy, nephropathy, and coronary artery disease, are determined by longitudinal follow-up of diabetic subjects. Methods of ascertainment of these complications include fundus photography, measurement of urine albumin and serum creatinine concentrations, and electrocardiography. Results of a segregation analysis suggest a major effect of a single gene on risk of nephropathy as a function of duration of diabetes. The group is taking part in a multicentered genetic linkage study (Family Investigation of Nephropathy and Diabetes) of diabetic nephropathy in an attempt to identify such a susceptibility gene.

该项目的目的是确定2型糖尿病的慢性并发症的发病率，进展率和危险因素。这项研究是在吉拉河印度社区的皮马印第安人进行的，他们自1965年以来就参加了一项纵向流行病学研究（请参阅Z01 DK 69000项目）。糖尿病，视网膜病，肾病和冠状动脉疾病的主要并发症的危险因素由糖尿病患者的纵向随访确定。确定这些并发症的方法包括眼底摄影，尿白蛋白和血清肌酐浓度的测量以及心电图。隔离分析的结果表明，单个基因对肾病风险的主要影响与糖尿病持续时间的关系。 该小组正在糖尿病性肾病的多中心遗传联系研究（对肾病和糖尿病的家庭研究），以试图识别这种敏感性基因。