DIABETES MELLITUS AND OTHER CHRONIC DISEASES IN THE GILA RIVER INDIAN COMMUNITY

吉拉河印第安社区的糖尿病和其他慢性疾病

• 批准号: 6289854
• 负责人: WILLIAM C KNOWLER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6289854
• 关键词: Native Americans; blood lipoprotein; body physical activity; child (0-11); clinical research; diabetes mellitus genetics; disease /disorder proneness /risk; family genetics; gender difference; gene expression; genetic markers; glucose tolerance; human mortality; human subject; hypertension; kidney disorder; locus of control; longitudinal human study; menstrual cycle disorder; noninsulin dependent diabetes mellitus; obesity; pathologic process; social psychology

The purpose of this project is to identify the determinants of type 2 diabetes, obesity, and other chronic diseases in the Pima Indians, and elucidate their natural history. Genetic and environmental risk factors for type 2 diabetes have been studied. The residents of the study area, approximately 5000 people, have participated in a longitudinal population study since 1965, allowing observations of the natural history of diabetes mellitus. Risk factors for obesity, hypertension, and nephropathy are also studied, along with the relationships of these diseases to diabetes and their effects on mortality rates. The genetics of diabetes is studied by means of family studies and relationships of genetic markers to disease. The roles of obesity, serum insulin concentrations, impaired glucose regulation, occupational and leisure- time physical activity and diabetes in relatives are assessed. Studies of the genetics of type 2 diabetes and obesity are described in project report # Z01 DK 69028-11 PECR. - Diabetes mellitus, obesity, insulin - Human Subjects

该项目的目的是确定皮马印第安人中2型糖尿病，肥胖和其他慢性疾病的决定因素，并阐明其自然史。已经研究了2型糖尿病的遗传和环境危险因素。自1965年以来，研究区的居民约有5000人参加了一项纵向人口研究，从而可以观察到糖尿病的自然历史。还研究了肥胖，高血压和肾病的危险因素，以及这些疾病与糖尿病的关系及其对死亡率的影响。通过家庭研究和遗传标记与疾病的关系研究了糖尿病的遗传学。评估了肥胖，血清胰岛素浓度，葡萄糖调节受损，职业和休闲时间运动以及亲戚中糖尿病的作用。项目报告中描述了2型糖尿病和肥胖的遗传学的研究＃Z01 DK 69028-11 PECR。 - 糖尿病，肥胖，胰岛素 - 人类受试者