Biocompatible Pickering Nanoemulsions for Cosmetics Applications

用于化妆品应用的生物相容性 Pickering 纳米乳液

基本信息

批准号：
2902166
负责人：
金额：
--
依托单位：
University of Sheffield
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2902166
关键词：
Biocompatible Pickering Nanoemulsions Cosmetics Applications

项目摘要

Emulsions comprise microscopic droplets of a liquid (e.g. oil) dispersed within a second immiscible liquid (e.g. water). A Pickering emulsion is a special type of emulsion in which the droplets are coated with tiny particles, which prevent droplet coalescence. Ashland is a specialty chemicals company that has recently commercialised a sustainable soya bean-derived triglyceride oil, which has applications in sun care, skin care and colour cosmetics. Prof. Armes has two decades of experience in Pickering emulsions and has recently prepared a series of Pickering nanoemulsions by processing an initially coarse Pickering emulsion to generate much finer oil droplets (mean droplet diameter < 500 nm). Such processing is conducted in the presence of excess nanoparticles via high-pressure microfluidisation. As additional surface area is created, the new nascent oil droplets are coated by the excess nanoparticles, thus stabilising the nanoemulsion. In principle, Pickering nanoemulsion formulations should offer new applications for Ashland's proprietary oil because the smaller droplet size should lead to much faster skin penetration. The PhD student will design bespoke nanoparticles to prepare Pickering nanoemulsions using Ashland's proprietary oil, characterise such nanoemulsions utilising various analytical techniques, and evaluate potential applications in the context of home & personal care products.

乳液包含分散在第二不混溶液体（例如水）内的液体（例如油）的微小液滴。皮克林乳液是一种特殊类型的乳液，其中液滴涂有微小颗粒，可防止液滴聚结。亚什兰是一家特种化学品公司，最近将一种可持续的大豆甘油三酯油商业化，该油可应用于防晒、皮肤护理和彩妆领域。 Armes 教授在 Pickering 乳液方面拥有二十年的经验，最近通过处理最初粗糙的 Pickering 乳液以产生更细的油滴（平均液滴直径 < 500 nm），制备了一系列 Pickering 纳米乳液。这种加工是在过量纳米颗粒存在的情况下通过高压微流化进行的。随着额外表面积的产生，新的新生油滴被多余的纳米颗粒所覆盖，从而稳定了纳米乳液。原则上，Pickering 纳米乳液配方应该为亚什兰的专有油提供新的应用，因为较小的液滴尺寸应该会导致更快的皮肤渗透。博士生将设计定制纳米颗粒，使用亚什兰的专有油制备 Pickering 纳米乳液，利用各种分析技术表征此类纳米乳液，并评估在家庭和个人护理产品中的潜在应用。