Biological Age and Capacity for Self-Management: Implications for Nursing

生物年龄和自我管理能力：对护理的影响

• 批准号: 7134805
• 负责人: KATHLEEN C INSEL
• 金额: $ 7.46万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-07 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7134805
• 关键词: aging; clinical research; executive function; hypertension; nurses; short term memory

DESCRIPTION (provided by applicant): The purpose of this investigation is to examine the association between biological age and executive function/working memory among individuals with hypertension. Prior investigations suggest executive function and working memory capacity are important cognitive processes essential for self-management. In addition to the importance of these processes to understanding self-management, it has been shown that executive function and working memory decline with age. This would seem to implicate age as a risk factor for failure to self-manage, for example, medications. This, however, has not been demonstrated. Several investigations suggest that chronological age is a poor predictor of self-management capacity and indeed that older adults may be better on some everyday tasks than young counterparts. While chronological age is not implicated in self-management, it is possible that biological age is a predictor of executive function/ working memory capacity in clinical populations accounting for differences in self-management. This descriptive correlational study uses telomere length as a marker for biological age and examines the association of telomere length to executive function/working memory capacity among individuals > 50 years of age self-managing one prescribed medication for hypertension. The study also identifies oxidative stress as a likely mechanism for accelerated biological aging in persons with hypertension. Oxidative stress will be quantified and associated with disease severity, biological age and executive function/working memory capacity. The study also seeks to provide converging evidence for the association between executive function/working memory capacity and medication adherence, an established self-management activity.

描述（由申请人提供）：本调查的目的是检查高血压患者的生物学年龄与执行功能/工作记忆之间的关联。先前的研究表明，执行功能和工作记忆能力是自我管理所必需的重要认知过程。除了这些过程对于理解自我管理的重要性之外，研究还表明，执行功能和工作记忆会随着年龄的增长而下降。这似乎暗示年龄是无法自我管理（例如药物治疗）的风险因素。然而，这一点尚未得到证实。多项调查表明，实际年龄并不能很好地预测自我管理能力，事实上，老年人在某些日常任务上可能比年轻人表现得更好。虽然实际年龄与自我管理无关，但生物年龄可能是临床人群执行功能/工作记忆能力的预测因子，解释了自我管理的差异。这项描述性相关研究使用端粒长度作为生物年龄的标志，并检查了 50 岁以上自我管理一种高血压处方药物的个体中端粒长度与执行功能/工作记忆能力的关系。该研究还确定氧化应激是高血压患者加速生物衰老的可能机制。氧化应激将被量化，并与疾病严重程度、生物学年龄和执行功能/工作记忆能力相关。该研究还试图为执行功能/工作记忆能力与药物依从性（一种既定的自我管理活动）之间的关联提供一致的证据。