IMMEDIATE EARLY GENE REGULATED DEVELOPMENT/PLASTICITY

立即早期基因调控的发育/可塑性

• 批准号: 7002631
• 负责人: WARREN G TOURTELLOTTE
• 金额: $ 13.65万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7002631
• 关键词: biological signal transduction; cAMP response element binding protein; cell biology; cell differentiation; cell proliferation; chromatin immunoprecipitation; congenital nervous system disorder; developmental genetics; developmental neurobiology; disease /disorder model; gene expression; genetic regulation; genetically modified animals; human genetic material tag; laboratory mouse; microarray technology; neural plasticity; neuroblastoma; neurogenesis; neurons; neurotrophic factors; protein structure function; regulatory gene; sympathetic nervous system; transcription factor

DESCRIPTION (provided by applicant): This is an Independent Scientist Award for Warren G. Tourtellotte, M.D., Ph.D. who is currently an Assistant Professor of Pathology, Neurology and Neuroscience at Northwestern University, Feinberg School of Medicine. Dr. Tourtellotte devotes greater than 75% professional effort to research focused on transcriptional regulation of genes involved in central and peripheral nervous system development. This Research Career Award will assure Dr. Tourtellotte stable salary support to allow him to commit 75% professional effort to research. The institution is supportive of a 75% research effort as evidenced by minimized clinical service commitments and recent expansion of the research space available to Dr. Tourtellotte. The career development plan will extend the focus of Egr transcription factor function in the laboratory to include studies of cellular physiology, signal transduction and genome wide regulatory network analysis. Dr. Tourtellotte will use the career development resources to strengthen collaborative networks both within the institution and externally to strengthen the research program by improving the methodology, scientific staff and expertise available to the laboratory. The Research Plan will characterize the role of Egr transcription factors in sympathetic nervous system development, neurotrophin mediated gene regulation and signal transduction. The planned career development activities will take full advantage of the rich collaborative and career development resources available at Northwestern University.

描述（由申请人提供）：这是授予 Warren G. Tourtellotte 医学博士、哲学博士的独立科学家奖。目前是西北大学范伯格医学院病理学、神经病学和神经科学助理教授。 Tourtellotte 博士将超过 75% 的专业精力投入到中枢和周围神经系统发育相关基因的转录调控研究上。该研究职业奖将为Tourtellotte博士提供稳定的薪资支持，使他能够将75%的专业精力投入到研究中。该机构支持 75% 的研究工作，这从最小化的临床服务承诺和最近扩大了 Tourtellotte 博士可用的研究空间即可证明。该职业发展计划将扩展实验室中Egr转录因子功能的重点，包括细胞生理学、信号转导和全基因组调控网络分析的研究。图尔泰洛特博士将利用职业发展资源来加强机构内部和外部的合作网络，通过改进实验室可用的方法、科学人员和专业知识来加强研究项目。该研究计划将描述 Egr 转录因子在交感神经系统发育、神经营养素介导的基因调控和信号转导中的作用。计划中的职业发展活动将充分利用西北大学丰富的协作和职业发展资源。