Aging in the Brain: The Role of the Fibrous Proteins
大脑衰老:纤维蛋白的作用
基本信息
- 批准号:7215320
- 负责人:
- 金额:$ 37.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1985
- 资助国家:美国
- 起止时间:1985-09-01 至 2012-04-30
- 项目状态:已结题
- 来源:
- 关键词:APP geneAblationAccountingAcuteAddressAdultAffectAffinityAffinity ChromatographyAgingAlanineAminesAnalysis of VarianceAnimal ModelAnimalsAntibodiesAreaAssesAstrocytesAutomobile DrivingAutoradiographyAxonBaltimoreBehaviorBindingBinding ProteinsBinding SitesBiochemicalBiologicalBiological AssayBiotinylationBlindedBlood capillariesBody cavitiesBrainBreedingBuffersC-terminalC83COS CellsCathetersCell CountCell CycleCell ExtractsCell LineCell NucleusCell Surface ReceptorsCell SurvivalCell membraneCell surfaceCellsCerebral VentriclesChemicalsChemistryChromatographyClassificationCleaved cellCloningCobaltCoculture TechniquesCognitiveColumn ChromatographyCompatibleComplementComplement component C1sComplementary DNAComplexComputer AssistedComputer softwareConditionConditioned Culture MediaCountCultured CellsCysteineCytoplasmic TailCytosineCytosolDNADataDatabasesDeoxyribonuclease IDeoxyribonucleasesDetectionDevelopmentDigestionDisruptionDisulfidesDominant-Negative MutationDoseDrosophila genusEffectivenessElectrodesElectroporationEmbryoEndocytosisEndoglycosidasesEndopeptidasesEnzyme-Linked Immunosorbent AssayEthylene GlycolsExtracellular DomainExtracellular MatrixFailureFamilyFamily memberFast GreenFigs - dietaryFlow CytometryFrequenciesGelGel ChromatographyGelatinGene FamilyGenerationsGenesGenetic TranscriptionGenomeGiftsGlassGleanGliomaGlycineGlycoproteinsGlycoside HydrolasesGoalsGold AlloysGrantGreen Fluorescent ProteinsGuanidinesGuidelinesHamstersHandHand PlateHarvestHeadHelix (Snails)Helper-Inducer T-LymphocyteHeparinHeparin BindingHippocampus (Brain)Histone H3Homologous GeneHornsHourHousingHumanHydrophobic InteractionsImageImmigrationImmobilizationImpairmentImplantIn VitroIncubatedIndianaInfusion proceduresInjection of therapeutic agentIntegrinsInterruptionIon ExchangeIonic StrengthsIonsIsoelectric FocusingKidneyKineticsKnock-outKnockout MiceLabelLaboratoriesLamininLengthLentivirus VectorLifeLigand BindingLigandsLightLinkLocalizedLocationLotionLysineMammalsMass Spectrum AnalysisMeasuresMediatingMembraneMembrane ProteinsMetabolicMetabolismMethodsMicroscopeMissense MutationMitoticMolecularMonitorMorphologyMusMuscleMutationN-terminalNatureNeedlesNeuraminidaseNeuritesNeuro-Oncological Ventral Antigen 2NeuroblastomaNeurogliaNeuronsNuclearNumbersOrganellesOrphanParentsPathway interactionsPatient currently pregnantPatternPediatric HospitalsPeptide HydrolasesPeptide N-glycohydrolase FPhenotypePhosphate BufferPhosphorylationPhysiologic pulsePhysiologicalPlasmidsPositioning AttributePreparationPrincipal InvestigatorProceduresProcessProductionProgress ReportsPropertyProtein BindingProtein IsoformsProtein MicrochipsProtein OverexpressionProteinsProteolysisProteolytic ProcessingProteomicsProtocols documentationPublishingPulse takingPuncture procedureRNARNA SplicingRadialRadiolabeledRangeRateRattusReactionReaderReadingReagentRegulationRelative (related person)ResearchResearch PersonnelResolutionRetroviridaeRodent ModelRoleSamplingScientistScreening procedureSepharoseSeriesSerumSideSignal PathwaySignal TransductionSignal Transduction PathwaySilver StainingSiteSliceSmall Interfering RNASodium BicarbonateSodium ChlorideSourceSpecificitySpottingsStaining methodStainsStem cellsStructureSubfamily lentivirinaeSurfaceSurveysSuspension substanceSuspensionsSwedish mutationSynapsinsSynaptic VesiclesSystemTechniquesTechnologyTestingTimeTissuesTransactivationTransfectionTransgenesTransgenic MiceTransgenic OrganismsTriton X100TrypsinTubulinTunicamycinUbiquitin CUreaUterusV717FVertebral columnViral VectorVirusVirus DiseasesWestern BlottingWorkage relatedamyloid precursor protein ligandamyloid precursor protein processingbody cavitycapillarycell motilitycell preparationchloramine-Tcinnamic acidcohortcomparativecrosslinkdaydesigndigital imagingdimerdisulfide bondear helixethylene glycolexperienceextracellularfibrous proteinglycosylationguanidiniumimprovedin uteroin vivoinjuredinsightinstrumentinterestkillingsknock-downlateral ventriclemass spectrometermembermetabisulfitemigrationmillisecondmonomermouse modelmutantnerve stem cellnestin proteinneuroblastneurophysiologynotch proteinnovelparaformpostnatalpresenilinpreventprogramspromoterprotein purificationpupradioligandradiotracerreceptorreceptor bindingrelating to nervous systemresearch studyresponsesecretasesmall moleculestatisticssulfationsurface enhanced laser desorption ionizationtraffickingtransgene expressionvectorvoltage
项目摘要
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
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DENNIS J SELKOE的其他文献
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