CSHL Cellular Biology of Addiction

CSHL 成瘾细胞生物学

• 批准号: 7035885
• 负责人: TERRI I. GRODZICKER
• 金额: $ 5.77万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7035885
• 关键词: brain imaging /visualization /scanning; cell biology; drug addiction; drug tolerance; genotype; informatics; meeting /conference /symposium; molecular biology; neuroanatomy; neurobiology; phenotype; travel; workshop

DESCRIPTION (provided by applicant): The primary objective of the proposed workshop is to provide an intense discussion of the fundamentals, state of-the-art advances and major gaps in the cell and molecular biology of drug addiction. Targeted to both new or experienced investigators, the workshop will combine formal presentations and informal discussions to convey the merits and excitement of cellular and molecular approaches to drug addiction research. The workshop will stress the significance of this approach not only to the most costly neuropsychiatric disorder addiction, but its applicability to learning, memory, neurochemical correlates of reward, perception and other disciplines of neuroscience. Research on the molecular and cellular changes that occur in response to drugs is critical for clarifying whether adaptive processes are diverse for each stage of addiction and for each drug of abuse. With the advent of genomics and proteomics, an extraordinary opportunity now exists to develop comprehensive models of neuroadaptative processes fundamental to addiction, craving, and relapse to drug use. The workshop will provide attendees with a spectrum of disciplines that can contribute to developing comprehensive models of each stage of drug addiction. The following disciplines will be presented: 1. an overview of addiction; 2. the contribution of noninvasive brain imaging to identifying drug targets and adaptive processes; 3. the association between neuroadaptative processes to drugs and behavioral manifestations; 4. linking genotype to drug response; 5. tolerance sensitization and adaptation at the cellular level; 6. regulation of receptor, enzyme function and associated neural activity. This workshop will provide an integrated view of current and novel research on neuroadaptive responses to addiction, foster discussion on collaboration and integration and provide critical information needed to construct a model of addiction as a disease and novel molecular targets for biological treatments. Beyond the plane of scientific endeavor, such information is vital for formulating public policy and for enlightening the public on the neurobiological consequences of drug use and addiction. The proposed workshop will generate intense interest, open conduits for collaborations and novel routes to investigating the neurobiology of addiction.

描述（由申请人提供）：拟议研讨会的主要目标是对药物成瘾的细胞和分子生物学的基本原理、最新进展以及主要差距进行深入讨论。该研讨会针对新的或经验丰富的研究人员，将结合正式的演讲和非正式的讨论来传达细胞和分子方法在药物成瘾研究中的优点和兴奋。研讨会将强调这种方法不仅对代价最高的神经精神疾病成瘾的重要性，而且还适用于学习、记忆、奖励的神经化学相关性、感知和神经科学的其他学科。对药物反应中发生的分子和细胞变化的研究对于阐明适应过程对于成瘾的每个阶段和每种药物滥用是否不同至关重要。随着基因组学和蛋白质组学的出现，现在存在一个绝佳的机会来开发对成瘾、渴望和吸毒复发至关重要的神经适应过程的综合模型。该研讨会将为与会者提供一系列学科知识，有助于开发毒瘾各个阶段的综合模型。将介绍以下学科： 1. 成瘾概述； 2. 无创脑成像对识别药物靶点和适应性过程的贡献； 3. 药物的神经适应过程与行为表现之间的关联； 4. 将基因型与药物反应联系起来； 5.细胞水平的耐受敏化和适应； 6.受体、酶功能和相关神经活动的调节。本次研讨会将提供对成瘾神经适应性反应的当前和新颖研究的综合看法，促进关于合作和整合的讨论，并提供构建成瘾疾病模型和生物治疗的新分子靶点所需的关键信息。除了科学努力之外，这些信息对于制定公共政策和启发公众了解吸毒和成瘾的神经生物学后果至关重要。拟议的研讨会将引起强烈的兴趣，开放合作渠道和研究成瘾神经生物学的新途径。