5th International Symposium on Hormonal Carcinogenesis

第五届激素致癌作用国际研讨会

• 批准号: 7224668
• 负责人: Jonathan J. Li
• 金额: $ 3.27万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-18 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7224668
• 关键词: androgens; cancer prevention; hormone related neoplasm /cancer; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): The primary goal of the 5th International Symposium on Hormonal Carcinogenesis (ISHC) is to gather a diverse group of research investigators, epidemiologists, basic scientists and clinicians to address the role of steroid and peptide hormones and growth factors in the causation, dependence, and eventual hormonal resistance of some of the most prevalent cancers afflicting women and men in the USA and world-wide. This ISHC will emphasize cutting edge progress in cancer research linking steroid hormones to: 1) Stem cell research, 2) Over-expression of mitotic kinases, 3) Significance of steroid hormone receptors in the evolution of hormone-dependent to -independent tumors, 4) Role of steroid receptors in solid tumors from non-hormone dependent tissues such as lung and colon, and 5) Development of therapeutic strategies derived from these discoveries. The planned program for this Symposium is well balanced. It includes sessions of primary interest to basic scientists that emphasize the molecular events leading to oncogenesis, hormone dependency and independency, and others of strong clinical relevance to physicians with a sound translational (pre-clinical) component. The prominent group of speakers includes women and under-represented minorities. The 5th ISHC scientific program has been divided into four areas linked to specific issues pertinent to hormonal carcinogenesis and hormonal cancers. Area 1: ETIOLOGY IN RELATION TO HORMONAL CANCERS. a) Cellular origin in adult breast and prostate cancer stem cells, Session 1 and 1st State of the Art presentation. b) Mitotic kinases, amplified centrosomes, and genomic instability in breast, prostate, hematologic malignancies, Session 2 and 3rd State of the Art presentation. c) Steroid receptor interactions, Session 3. Area 2: HORMONE-RELATED CANCER RISK FACTORS. d). Risk assessment, biomarkers, and hormone receptors in breast, ovary, prostate, colorectal, lung, Sessions 4, 7, and 2nd State of the Art presentation. Area 3: PREVENTION AND TREATMENT. e) In relation to breast, prostate, and ovarian cancer, Session 5 and 2nd State of the Art presentation. Area 4: Hormone Dependency and Independency. e) In prostate, breast and uterine cancer, Session 6. As in the past, a book will be published of the presentations.

描述（由申请人提供）：第五届激素致癌作用国际研讨会 (ISHC) 的主要目标是聚集不同的研究人员、流行病学家、基础科学家和临床医生，讨论类固醇和肽激素以及生长因子在癌症中的作用。美国和世界各地女性和男性最常见的一些癌症的因果关系、依赖性和最终的激素抵抗。 该 ISHC 将强调将类固醇激素与以下方面联系起来的癌症研究的前沿进展：1) 干细胞研究，2) 有丝分裂激酶的过度表达，3) 类固醇激素受体在激素依赖性肿瘤向非依赖性肿瘤进化中的重要性，4 ) 类固醇受体在肺和结肠等非激素依赖性组织实体瘤中的作用，以及 5) 从这些发现中衍生出的治疗策略的开发。 本次研讨会的计划安排非常平衡。 它包括基础科学家主要感兴趣的会议，强调导致肿瘤发生、激素依赖性和独立性的分子事件，以及与医生具有良好的转化（临床前）成分的其他与临床密切相关的会议。 突出的演讲者群体包括女性和代表性不足的少数群体。 第五届 ISHC 科学计划分为四个领域，涉及与激素致癌和激素癌症相关的具体问题。 领域 1：与激素癌症相关的病因学。 a) 成人乳腺癌和前列腺癌干细胞的细胞起源，第 1 场和第 1 场最新技术演示。 b) 有丝分裂激酶、扩增中心体以及乳腺癌、前列腺、血液恶性肿瘤中的基因组不稳定性，第 2 场和第 3 场最新技术演示。 c) 类固醇受体相互作用，第 3 场。区域 2：激素相关癌症风险因素。 d).乳房、卵巢、前列腺、结直肠、肺的风险评估、生物标志物和激素受体，第 4 节、第 7 节和第二次最新技术演示。 领域 3：预防和治疗。 e) 关于乳腺癌、前列腺癌和卵巢癌，第 5 场和第二次最新技术演示。 区域 4：激素依赖性和独立性。 e) 前列腺癌、乳腺癌和子宫癌，第 6 场。与过去一样，将出版有关演讲的书。