Animal Models in Type 1 Diabetes and Multiple Sclerosis

1 型糖尿病和多发性硬化症的动物模型

• 批准号: 7169720
• 负责人: Matthias G. Von Herrath
• 金额: $ 2.1万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7169720
• 关键词: disease /disorder model; insulin dependent diabetes mellitus; meeting /conference /symposium; multiple sclerosis; travel

DESCRIPTION (provided by applicant): The New York Academy of Sciences is planning a two day conference entitled "Animal Models for Type 1 Diabetes and Multiple Sclerosis" to take place November 8 and 9, 2006 in San Francisco, CA. The organizers of this conference are Drs. Matthias von Herrath (LaJolla Institute for Allergy and Immunology), David Hafler (Harvard University), Mark Atkinson (University of Florida, Gainesville) and Bart Roep (Leiden University, The Netherlands). Animal models have been used to understand the pathogenesis of autoimmune diseases and guide us towards novel immune-based interventions. Despite their popularity in research, their ability to provide simple answers to the complex issues of the causes of and means for the prevention of autoimmune disorders has been somewhat limited. The purpose of this conference is to bring together leaders in the fields of type 1 diabetes and multiple sclerosis to discuss and debate crucial questions regarding the proper use of animal models for studies of human disease. Central themes for this conference will include the necessity for novel and improved models, the optimal use of information from animal models to understand pathogenesis of the human disease, and the rational development of novel immunotherapeutics. The goal of this meeting is to identify common standardized grounds for the optimal application of established and novel animal models for both basic discovery and therapeutic translation. Lessons learned from two autoimmune diseases will cross fertilize the discourse. We anticipate that the audience for this conference will encompass researchers working in basic science, pre-clinical science, translational medicine and clinical medicine in both academia and industry. Additionally, we expect that this symposium will be of interest to junior faculty working in the areas of autoimmune disease research, as well as patient advocacy groups.

描述（由申请人提供）： 纽约科学院计划于 2006 年 11 月 8 日至 9 日在加利福尼亚州旧金山举行为期两天的会议，题为“1 型糖尿病和多发性硬化症的动物模型”。本次会议的组织者是 Drs. Matthias von Herrath（拉霍亚过敏和免疫学研究所）、David Hafler（哈佛大学）、Mark Atkinson（佛罗里达大学盖恩斯维尔分校）和 Bart Roep（荷兰莱顿大学）。动物模型已被用来了解自身免疫性疾病的发病机制，并指导我们采取新的基于免疫的干预措施。尽管它们在研究中很受欢迎，但它们为自身免疫性疾病的原因和预防手段等复杂问题提供简单答案的能力受到一定限制。本次会议的目的是汇集 1 型糖尿病和多发性硬化症领域的领导者，讨论和辩论有关正确使用动物模型研究人类疾病的关键问题。本次会议的中心主题将包括新型和改进模型的必要性、最佳利用动物模型信息来了解人类疾病的发病机制，以及新型免疫疗法的合理开发。这次会议的目标是确定共同的标准化基础，以优化应用已建立的和新颖的动物模型来进行基础发现和治疗转化。从两种自身免疫性疾病中汲取的经验教训将使讨论更加丰富。我们预计本次会议的观众将包括学术界和工业界从事基础科学、临床前科学、转化医学和临床医学的研究人员。此外，我们预计本次研讨会将会引起自身免疫性疾病研究领域的初级教师以及患者倡导团体的兴趣。