Stem Cells in Organ Maintenance and Repair

干细胞在器官维护和修复中的作用

• 批准号: 7224651
• 负责人: LLOYD G CANTLEY
• 金额: $ 1.2万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2007-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7224651
• 关键词: health science research support; kidney disorder; meeting /conference /symposium; regeneration; stem cells; travel

DESCRIPTION (provided by applicant): The American Society of Nephrology holds a meeting each year at which experts in kidney research and clinical care gather from around the world for 4 days to present their studies on the latest aspects of kidney disease and treatment. During the 2 days immediately prior to that annual meeting, the ASN sponsors a basic science conference for a smaller audience focused on a specific area of current interest to the kidney research community. For 2006, this 2 day conference will be "Stem Cells in Organ Maintenance and Repair," and is designed to bring together world experts in stem cell research with young scientists interested specifically in kidney-related research. With this format, members of the kidney research community will be exposed to the latest techniques in adult stem cell research, and develop collaborations with scientists who are recognized experts in the field of stem cell research. The current grant application asks for funds to provide partial financial support to cover the costs of registration and lodging for junior scientists who wish to attend this conference. Our goal is to provide support for young scientists so that they can obtain the knowledge necessary to perform studies that will determine the usefulness of stem cells in treating patients with a variety of kidney diseases. Stem cells have attracted a vast degree of attention and interest in the biomedical research community. This has led to a marked increase in the number of studies being performed around the world examining the role of stem cells in organ maintenance and repair. Due to the present lack of specific information defining stem cells in various organs, and the controversy surrounding the issue of whether or not adult bone marrow stem cells are able to cross organ boundaries and participate in repair of other organs, many of these studies have failed to advance our understanding of the clinical potential of stem cells in human disease, including kidney disease. For this reason the current basic science conference entitled "Stem Cells in Organ Maintenance and Repair" has been organized to bring together world experts in stem cell research and interested members of the renal research community to facilitate the exchange of information and foster collaborations aimed at developing definitive studies regarding the potential use of stem cells in the treatment of kidney diseases. The speakers will address four general areas: 1) the characteristics that define stem cells, 2) the factors that create a stem cell niche, 3) organ-specific stem cells, and 4) the role of stem cells in organ repair. Our goal is to provide partial financial support for young scientists to attend this meeting in order to ensure that studies proposed to the NIH by these investigators will be designed in a manner that will elucidate the potential use of stem cells in the treatment of kidney diseases.

描述（由申请人提供）： 美国肾脏病学会每年举行一次会议，来自世界各地的肾脏研究和临床护理专家齐聚一堂，为期 4 天，展示他们关于肾脏疾病和治疗的最新研究成果。在该年会之前的 2 天，ASN 主办了一次针对较小受众的基础科学会议，重点关注肾脏研究界当前感兴趣的特定领域。 2006 年，这个为期 2 天的会议将是“干细胞在器官维护和修复中的作用”，旨在将干细胞研究领域的世界专家与对肾脏相关研究特别感兴趣的年轻科学家聚集在一起。通过这种形式，肾脏研究界的成员将接触到成体干细胞研究的最新技术，并与干细胞研究领域公认的专家科学家开展合作。当前的拨款申请要求资金提供部分财务支持，以支付希望参加本次会议的初级科学家的注册和住宿费用。我们的目标是为年轻科学家提供支持，使他们能够获得进行研究所需的知识，从而确定干细胞在治疗各种肾脏疾病患者中的有效性。干细胞引起了生物医学研究界的广泛关注和兴趣。这导致世界各地进行的研究干细胞在器官维护和修复中的作用的研究数量显着增加。由于目前缺乏定义各器官中干细胞的具体信息，以及围绕成体骨髓干细胞是否能够跨越器官边界并参与其他器官修复问题的争议，许多研究都失败了增进我们对干细胞在人类疾病（包括肾脏疾病）中的临床潜力的了解。因此，组织了当前题为“干细胞在器官维护和修复中的作用”的基础科学会议，汇集了干细胞研究领域的世界专家和肾脏研究界感兴趣的成员，以促进信息交流并促进合作，旨在开发关于干细胞治疗肾脏疾病的潜在用途的明确研究。演讲者将讨论四个一般领域：1）定义干细胞的特征，2）创建干细胞生态位的因素，3）器官特异性干细胞，以及4）干细胞在器官修复中的作用。我们的目标是为参加本次会议的年轻科学家提供部分财政支持，以确保这些研究人员向 NIH 提出的研究的设计方式将阐明干细胞在肾脏疾病治疗中的潜在用途。