FASEB Conference -PKD Mechanisms and Clinical Impact

FASEB 会议 -PKD 机制和临床影响

• 批准号: 7000706
• 负责人: Lisa M Guay-Woodford
• 金额: $ 0.6万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-15 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7000706
• 关键词: kidney disorder; meeting /conference /symposium; pathology; polycystic kidney; travel

DESCRIPTION (provided by applicant): This application seeks partial support for the Federation of American Societies of Experimental Biology (FASEB) Summer Research Conference on "Polycystic Kidney Diseases: Molecular Pathways, Pathogenic Mechanisms and Translational Applications" to be held from August 6-11, 2005 in Saxtons River, VT. The planned conference follows a very successful, FASEB-sponsored inaugural conference that was held in August 2002. This meeting will highlight the exciting research progress in the interval three years, and thus provide a timely forum that integrates recent advances in basic research with applied themes. The conference will comprise a keynote address, nine regular scientific sessions, two 2-hour poster discussion sessions that will be organized based on the submitted abstracts (new, unpublished data), and a 2-hour session for late-breaking advances. The scientific program has been organized around three main themes. First, we will discuss the functional role of renal cystic disease proteins or cystoproteins in epithelial differentiation, polarity, and cell signaling, including their functional roles in signaling from the primary apical cilium. The second theme will take a broader view - examining cystoprotein function from a phylogenetic perspective; characterizing cystoprotein networks that are modulated by quantitative trait loci, and probing cystoprotein function in convergent pathways that have been implicated in phenotypically-diverse renal cystic diseases. The role of cystoproteins in non-renal epithelia and non-epithelial organs will also be explored. The final theme will have a translational focus - exploring biomarkers for disease progression and discussing targets for new and innovative therapies. The small size of the meeting (100-150 participants) with participants drawn from diverse disciplines ranging from nephrology and gasteroenterology, to cell biology and developmental biology, to molecular genetics and comparative genomics, to state-of-the-art imaging and pharmaceutical development, will provide an unparalleled opportunity for scientific cross-fertilization. By allowing ample time for scientific exchanges and critical discussion, the conference will serve as a conduit for exploring new experimental ideas and fostering new research collaborations.

描述（由申请人提供）： 本申请寻求美国实验生物学会联合会 (FASEB) 夏季研究会议“多囊肾病：分子途径、致病机制和转化应用”的部分支持，该会议将于 2005 年 8 月 6 日至 11 日在佛蒙特州萨克斯顿河举行。计划中的会议是在 2002 年 8 月举办的由 FASEB 主办的非常成功的首次会议之后举行的。这次会议将重点介绍三年来令人兴奋的研究进展，从而提供一个及时的论坛，将基础研究的最新进展与应用主题结合起来。 会议将包括一次主题演讲、九场常规科学会议、两场根据提交的摘要（新的、未发表的数据）组织的 2 小时海报讨论会议，以及一场 2 小时的最新进展会议。该科学计划围绕三个主题组织。首先，我们将讨论肾囊性疾病蛋白或囊蛋白在上皮分化、极性和细胞信号传导中的功能作用，包括它们在初级顶端纤毛信号传导中的功能作用。第二个主题将采取更广泛的视角——从系统发育的角度检查囊蛋白功能；表征由数量性状位点调节的囊蛋白网络，并探讨与表型多样化的肾囊性疾病有关的会聚途径中的囊蛋白功能。还将探讨囊蛋白在非肾上皮和非上皮器官中的作用。最后的主题将有一个转化焦点——探索疾病进展的生物标志物并讨论新的和创新疗法的目标。 会议规模较小（100-150 名与会者），与会者来自不同学科，包括肾病学和胃肠病学、细胞生物学和发育生物学、分子遗传学和比较基因组学、最先进的成像和药物开发，将为科学异花受精提供无与伦比的机会。通过留出充足的时间进行科学交流和批判性讨论，会议将成为探索新实验想法和促进新研究合作的渠道。