Protein Folding in the Cell

细胞中的蛋白质折叠

• 批准号: 7160205
• 负责人: RICHARD I MORIMOTO
• 金额: $ 1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-10 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7160205
• 关键词: cell biology; interdisciplinary collaboration; meeting /conference /symposium; molecular pathology; protein folding; travel

DESCRIPTION (provided by applicant): We request funding to support the 2006 Federation of American Society of Experimental Biologists (FASEB) Summer Conference on "Protein Folding in the Cell" to be held July 29 to August 3, 2006 in Saxtons River, VT. The proposed conference will be the ninth in a series of highly successful FASEB Conferences on this topic. This meeting has been unique in its goal to bring together cell biologists/geneticists, biophysicists/biochemists, and mathematical modelers to tackle the complex problems of protein folding and misfolding and implications for human disease. This was the concept behind the first conference in 1990, and it remains a unique opportunity for scientists from very diverse backgrounds. Most protein folding conferences consider either the theoretical and in vitro aspects of folding or the role of molecular chaperones and protein folding catalysts in the cell. However, the need for interdisciplinary approaches is stronger than ever. The cell biological approaches have progressed to where reaching a mechanistic understanding is crucial, and biological constraints play a critical role in formulating theory and interpreting in vitro data. In addition to examining recent advances in in vitro folding and molecular chaperone mechanism, this meeting will focus on the latest developments in the mechanisms of protein folding and misfolding, and the related cellular processes of protein synthesis, sorting and translocation through the cell and across membranes, macromolecular assembly, and protein degradation. Whereas past "Protein Folding in the Cell" meetings have alternated between emphases on in vitro folding and biophysical topics or cellular aspects of folding in vivo, a new aspect of the 2006 meeting will be to integrate these topics. Common themes include diseases of protein conformation including neurodegenerative diseases, amyloidoses, and cystic fibrosis and how the proteins implicated in these diseases have provided insights into the protein quality control machinery and on the intrinsic properties of folding, misfolding, and assembly into oligomers and fibrils. Finding therapeutic strategies requires a fundamental understanding of the behavior of the polypeptide chain and the cellular environment and constraints imposed on it. Our goal through this meeting is to bring together physical and biological scientists in an interactive environment, to promote education and understanding of the approaches, experimental limitations and to explore common interests. The small size and isolated setting of this meeting with all participants residing and taking their meals in close proximity promotes optimal scientific exchange. The conference format will provide extensive arenas for informal discussions. Poster sessions will allow all participants to interact scientifically with other investigators. Young investigators and women will be well-represented among speakers and encouraged to attend the conference.

描述（由申请人提供）：我们请求资金支持将于 2006 年 7 月 29 日至 8 月 3 日在佛蒙特州萨克斯顿河举行的 2006 年美国实验生物学家协会 (FASEB) 夏季会议“细胞中的蛋白质折叠”。拟议的会议将是关于该主题的一系列非常成功的 FASEB 会议中的第九次。这次会议的独特之处在于其目标是将细胞生物学家/遗传学家、生物物理学家/生物化学家和数学建模师聚集在一起，共同解决蛋白质折叠和错误折叠的复杂问题以及对人类疾病的影响。这是 1990 年第一次会议背后的理念，对于来自不同背景的科学家来说，这仍然是一个独特的机会。大多数蛋白质折叠会议要么考虑折叠的理论和体外方面，要么考虑分子伴侣和蛋白质折叠催化剂在细胞中的作用。然而，对跨学科方法的需求比以往任何时候都更加强烈。细胞生物学方法已经发展到达到机械理解至关重要的地步，而生物学限制在制定理论和解释体外数据方面发挥着关键作用。本次会议除了探讨体外折叠和分子伴侣机制的最新进展外，还将重点关注蛋白质折叠和错误折叠机制的最新进展，以及蛋白质合成、分选和跨细胞和跨膜的相关细胞过程。 、大分子组装和蛋白质降解。过去的“细胞内蛋白质折叠”会议交替强调体外折叠和生物物理主题或体内折叠的细胞方面，2006 年会议的一个新方面将是整合这些主题。常见主题包括蛋白质构象疾病，包括神经退行性疾病、淀粉样变性和囊性纤维化，以及这些疾病中涉及的蛋白质如何提供对蛋白质质量控​​制机制以及折叠、错误折叠和组装成寡聚物和原纤维的内在特性的见解。寻找治疗策略需要对多肽链的行为和细胞环境以及对其施加的限制有基本的了解。我们通过这次会议的目标是将物理和生物科学家聚集在一个互动的环境中，促进对方法、实验局限性的教育和理解，并探索共同的兴趣。本次会议规模较小，环境孤立，所有与会者居住和就餐的距离都很近，促进了最佳的科学交流。会议形式将为非正式讨论提供广泛的场所。海报会议将使所有参与者能够与其他研究人员进行科学互动。年轻的研究人员和女性将在演讲者中得到充分代表，并被鼓励参加会议。