6th International Podocyte Conference

第六届国际足细胞会议

• 批准号: 7162474
• 负责人: Stuart James Shankland
• 金额: $ 1万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162474
• 关键词: kidney disorder; meeting /conference /symposium; podocyte; travel

DESCRIPTION (provided by applicant): The purpose of this application is to request financial support from the NIH for the 6th International Podocyte Symposium to be held June 8-11, 2006 in Helsinki, Finland. The podocyte (also called visceral glomerular epithelial cell), is a terminally differentiated cell that is the target of injury in diabetic (1) and non-diabetic kidney diseases (2), resulting in chronic and endstage renal failure. The incidence of chronic and endstage renal disease is increasing annually in the US at an alarming rate (3). There are a number of reasons for this, including the burden of complications related to diabetes (diabetic nephropathy) and hypertension. Both the nephritic and nephrotic forms of glomerular disease remain leading causes of kidney failure worldwide. It is predicted that the major cause of renal disease in Africa in the next decade will be HIV associated nephropathy, which is a disease characterized by injury primarily to the podocyte. Studies have shown that nephrotic syndrome is primarily a disease of the podocyte. The leading causes of nephrotic syndrome in adults includes focal segmental glomerulosclerosis (FSGS), membranous nephropathy, minimal change disease and diabetic nephropathy. The leading cause of nephrotic syndrome in children is minimal change disease. However, studies have also shown that podocyte number is a critical determinant of prognosis in nephritic diseases such as IgA nephropathy, the leading cause of nephritis worldwide (4). Taken together, understanding of the latest developments in podocyte biology and pathobiology is critical to the future treatment of glomerular disease. Moreover, this is an exciting era in podocytes biology given the large body of literature that has been published in the past 2-5 years.

描述（由申请人提供）：本申请的目的是为将于 2006 年 6 月 8 日至 11 日在芬兰赫尔辛基举行的第六届国际足细胞研讨会请求 NIH 的资助。足细胞（也称为内脏肾小球上皮细胞）是一种终末分化细胞，是糖尿病 (1) 和非糖尿病肾病 (2) 损伤的目标，导致慢性和终末期肾衰竭。在美国，慢性和终末期肾病的发病率每年以惊人的速度增加 (3)。造成这种情况的原因有很多，包括与糖尿病（糖尿病肾病）和高血压相关的并发症的负担。肾小球疾病的肾炎和肾病形式仍然是全世界肾衰竭的主要原因。据预测，未来十年非洲肾病的主要原因将是艾滋病毒相关肾病，这是一种主要以足细胞损伤为特征的疾病。研究表明，肾病综合征主要是足细胞疾病。成人肾病综合征的主要原因包括局灶节段性肾小球硬化症（FSGS）、膜性肾病、微小病变和糖尿病肾病。儿童肾病综合征的主要原因是微小病变性疾病。然而，研究还表明，足细胞数量是 IgA 肾病等肾病疾病预后的关键决定因素，IgA 肾病是全世界肾炎的主要原因 (4)。总而言之，了解足细胞生物学和病理学的最新进展对于肾小球疾病的未来治疗至关重要。此外，鉴于过去 2-5 年发表的大量文献，这是足细胞生物学的一个激动人心的时代。